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目的：探讨雾化吸入糖皮质激素治疗慢性阻塞性肺病急性加重期（AECOPD）的临床效果。方法：60例AECOPD患者随机分为治疗组和对照组，对照组给予抗感染、吸氧、化痰等常规治疗，治疗组在常规治疗的基础上给予糖皮质激素雾化吸入治疗，连续治疗14d后评价临床疗效，观察治疗前后两组患者的临床症状和肺功能改善情况。结果：治疗组临床疗效有效率为96.7%，高于对照组（80.0%），相比较有显著性差异（P<0.05）；治疗组临床症状评分和呼吸困难评分与治疗前和对照组比较显著下降，相比较有显著性差异（P<0.05）；治疗组FEV1、FEV水平与治疗前和对照组比较显著上升，肺功能改善显著，相比较有显著性差异（P<0.05）。结论：雾化吸入糖皮质激素治疗AECOPD疗效肯定，值得临床推广应用

英文摘要:

Objective: To evaluate the inhalation efficacy of corticosteroid in acute exacerbation of chronic obstructive pulmonary disease（AECOPD）therapy. Methods: A total of 60 patients with AECOPD were randomly divided into treatment group and control group. The control group was conventional treatment of antibiotics, oxygen, phlegm, and so on. On the basis of conventional treatment the treatment group were given inhaled corticosteroid therapy. 14d after continuous treatment the clinical effect was evaluated, the clinical symptoms and lung function of prior-treatment and post-treatment between two groups were observed. Results: The clinical efficiency of the treatment group was 96.7%, the control group was 80.0%, compared the difference between two groups was significant (P <0.05); The clinical symptoms and difficulty breathing scores of post-treatment were higher than prior-treatment and the control group, compared the difference was significant (P <0.05); The FEV1 and FEV levels of the treatment group were higher than prior-treatment and the control group, lung function improved significantly, compared the difference was significant (P <0.05). Conclusion: The inhaled corticosteroid therapy is effective and worthy of clinical application.

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