| 贺小燕1 王海琳2△ 陈晓红1 陈丑彦1.HMGB1在卵巢癌中的表达及临床意义[J].现代生物医学进展英文版,2011,11(4):695-697. |
| HMGB1在卵巢癌中的表达及临床意义 |
| Expression and clinical significance of HMGB1 in ovarian carcinoma |
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| DOI： |
| 中文关键词: HMGB1 卵巢癌 肿瘤标志物 免疫组织化学 |
| 英文关键词: HMGB1 Ovarian cancer Tumor markers Immunohistochrmistry |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨高迁移率组蛋白B1（HMGB1）在卵巢癌患者血清及组织中的表达及临床意义。方法：采用ELISA技术检测96例
女性血清中HMGB1 水平，其中盆腔肿物住院患者66 例按照术后病理结果分为卵巢良性肿瘤组40 例和卵巢癌组26 例,健康女
性30 例作为正常对照组, 并通过免疫组织化学技术进一步检测卵巢癌、卵巢良性肿瘤组织中的表达情况。结果：卵巢癌组
HMGB1水平明显高于其他两组，差异有统计学意义（P<0.05）,正常对照组和卵巢良性肿瘤组比较差异无统计学意义（P>0.05）。结
论：HMGB1测定有助于鉴别卵巢良恶性肿瘤。 |
| 英文摘要: |
| Objective: To explore the expression and clinical significance of HMGB1 in ovarian carcinoma. Methods: ELISA
method was used to detect the expression of serum HMGB1 in 26 ovarian carcinoma, 40 benign ovarian tumor and 30 healthy women.
Moreover, Immunohistochemical SABC method was used to detect the expression of HMGB1 in 26 ovarian carcinoma tissues and 40
benign ovarian tumor tissues. Results: The expression of HMGB1 were higher in ovarian carcinoma than that in the others, showing a
significant difference (P<0.05). There were no significant diference between normal control group and benign ovarian tumor group(P>0.
05). Conclusion: The expression of HMGB1 might be as one of the parameters for identifying benign ovarian tumor and ovarian carcinoma. |
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