| 张筠王建平.骨桥蛋白与糖尿病肾病关系的研究进展[J].现代生物医学进展英文版,2011,11(3):598-600. |
| 骨桥蛋白与糖尿病肾病关系的研究进展 |
| The advances of relationship between osteopontin and diabetic nephropathy |
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| DOI： |
| 中文关键词: 骨桥蛋白糖尿病肾病蛋白尿炎症反应 |
| 英文关键词: Osteopontin Diabetic nephropathy Proteinuria Inflammation |
| 基金项目:湖南省教育厅科学研究项目（09C844） |
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| 中文摘要: |
| 骨桥蛋白(OPN)是一种具有细胞粘附和迁移功能的分泌型磷酸化糖蛋白。在肾脏中有广泛分布，研究发现其参与糖尿病肾
病(DN)蛋白尿形成、DN的炎症反应及肾脏纤维化过程，抑制OPN可改善糖尿病肾脏病变。 |
| 英文摘要: |
| Osteopontin is a kind of secreted glycoprotein of phosphorylated for cellular adhesion and migration. It is a wide range
of distribution in the kidney. Studies have shown that it is involved in the formation of proteinuria，inflammation and fibrosis on the diabetic
nephropathy. Inhibition of osteopontin can improve diabetic nephropathy. |
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