| 曹秀峰吕进.食管鳞癌相关基因与预后及临床病理关系的研究进展[J].现代生物医学进展英文版,2011,11(3):588-592. |
| 食管鳞癌相关基因与预后及临床病理关系的研究进展 |
| Association of genes with the prognosis and clinical pathology aboutesophageal squamous cell carcinoma |
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| DOI： |
| 中文关键词: 食管鳞癌 基因 预后 临床病理 |
| 英文关键词: esophageal squamous cell carcinoma(ESCC) gene prognosis clinical pathology |
| 基金项目:南京市医学发展重点基金资助项目（ZKX0114） |
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| 中文摘要: |
| 食管鳞癌是一种多因素的疾病，除了环境因素可以影响食管癌发生和发展，分子水平的基因改变是近年研究的热点。近年
基因芯片技术的发展，已发现众多基因，如β-catenin、wnt1、p53、cyclin D1 以及EGFR 等基因表达的改变与食管鳞癌的发生、发
展或预后相关，从而可更好地寻找判断预后的分子指标，具有广阔的应用前景，但其与影响食管鳞癌预后的众多因素之间的关系
及其与临床病理的关系以及应用，仍需进一步研究。 |
| 英文摘要: |
| Esophageal squamous cell carcinoma is a multi-factor disease. In addition to the environmental factors, the molecular
genetic changes, which have been in research hot spot, can also influence the occurrence and development of esophageal cancer. In recent
years, with the development of gene chip technology, the scholars have found many gene expression changes, such as β-catenin,
wnt1, p53, cyclin D1 and EGFR, et al., are associated with the the development or prognosis of esophageal squamous cell carcinoma. So,
with potential applications, it may be the better molecular target to predict the prognosis. However, the prognosis of esophageal squamous
cell carcinoma and the impact of the relationship between many factors and clinical pathology and the application still need further study. |
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