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目的：观察探讨苯磺酸左旋氨氯地平治疗老年轻中度高血压患者的临床疗效和安全性。方法：160例老年轻中度高血压患者随机分为研究组与对照组，研究组给予苯磺酸左旋氨氯地平；对照组给予苯磺酸氨氯地平，治疗过程中进行24h 血压监测，总治疗8周为一疗程。结果：研究组4周末和8 周末的总有效率分别为78.75%和96.25%，显著高于对照组的53.75%和86.25%，差异有统计学意义(P<0.05)。治疗前后两组的舒张压和收缩压均有明显降低，其中研究组收缩压平均下降(29.0±3.2) mmHg，舒张压平均下降(15.3±2.3) mmHg，对照组则分别下降(18.5±2.8) mmHg和(9.0±2.5) mmHg，差异具有统计学意义(P<0.05)。治疗8 周末的 24h、白昼和夜间的收缩压和舒张压均有明显降低，差异有统计学意义(P<0.05)，但治疗组下降更明显，与对照组比较差异有统计学意义(P<0.05)。治疗后两组的脉压均有明显降低，差异具有统计学意义(P<0.05)，但研究组下降更明显。结论：苯磺酸左旋氨氯地平治疗老年轻中度高血压临床疗效好，不良反应少，且对心脏具有保护功能。

英文摘要:

Objective: To observe the clinical efficacy and safety of levamlodipine besylate on mild and moderate hypertension in the elderly. Methods: A total of 160 patients with mild and moderate hypertension were randomly divided into research and control group. The research group was given levamlodipine besylate;the control group, amlodipine besylate, with a course of 8 weeks, respectively. Results:The total effective rates at the end of 4 and 8 weeks in the research group were 78.75% and 96.25%, higher than those (53.75% and 86.25%) in the control group (P<0.05). In the research group, the systolic blood pressure decreased (29.0 ±3.2) mmHg and diastolic blood pressure decreased (15.3 ±2.3) mmHg; in the control group, (18.5±2.8) mmHg and (9.0±2.5) mmHg, with statistically significant differences (P <0.05). Conclusion: Levamlodipine besylate is an effective and safety drug for the treatment of mild and moderate hypertension in the elderly, which can protecte the heart function.

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