| 高珊1 刘克坚2 邱强2△.冠心病患者低密度脂蛋白与血小板GMP-140水平相关性研究[J].现代生物医学进展英文版,2011,11(3):552-554. |
| 冠心病患者低密度脂蛋白与血小板GMP-140水平相关性研究 |
| Correlation of Low Density Lipoprotein Cholesterol and GMP-140in Patients with Coronary Heart Disease |
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| DOI： |
| 中文关键词: 冠心病 低密度脂蛋白 血浆α颗粒膜蛋白-140 |
| 英文关键词: coronary heart diseases low density lipoprotein cholesterol granular membranous protein |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨冠心病患者低密度脂蛋白与血小板功能活化产物GMP-140的关系。方法：应用酶联免疫分析法对120例研究对
象进行了血浆LDL、GMP-140 水平的测定,其中包括急性冠脉综合征组40 例，稳定性心绞痛组40 例,并与40 例正常健康人作比
较。结果：ACS患者血浆LDL和GMP-140水平均非常显著的高于正常人组(P＜0.01),ACS组又高于SAP组(P＜0.05), 且血浆
LDL与GMP-140水平呈正相关。结论：检测CHD患者血浆LDL和GMP-140水平的变化对CHD的发生和发展以及疗效和预后
观察均具有重要的临床意义。 |
| 英文摘要: |
| Objective: To study the correlation between LDL and GMP-140 in Coronary Heart Disease. Methods: LDL and
GMP-140 levels (with ELISA) were determined in 80 patients with CHD (40 ACS, 40SAP) and 40 controls. Results: LDL and GMP-140
levels in patients with CHD were significantly higher than those in controls(P＜0.01). Among the CHD patients, magnitude of changes of
the levels of LDL and GMP-140 in ACS groups were larger than those in SAP groups（P＜0.05). LDL levels were positively correlated
with GMP-140 levels. Conclusion: The LDL and GMP-140 levels were closely related to the diseases process of CHD and were of great
clinical importance. |
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