| 崔世义1 孙伟2△ 陈旭伟1.HDAC1蛋白在乳腺癌中的表达及临床意义及与ER、PR的关系[J].现代生物医学进展英文版,2011,11(3):541-545. |
| HDAC1蛋白在乳腺癌中的表达及临床意义及与ER、PR的关系 |
| Expression of histone deacetylase1 in breast carcinoma and its clinicalsignificance |
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| DOI： |
| 中文关键词: 乳腺肿瘤 组蛋白去乙酰化酶 免疫组织化学法 |
| 英文关键词: Breast neoplasms Histone deacetylases Immunohistochemistry |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨乳腺癌组织中组蛋白去乙酰化酶1（HDAC1）的表达及临床意义。方法：应用免疫组织化学SP法检测78例乳腺
癌组织和20 例癌旁组织中HDAC1 蛋白的表达情况并分析其与ER、PR 之间的关系。结果：（1）HDAC1 蛋白在78 例乳腺癌中
的阳性表达率为78.2%(61/78)，在癌旁组织中的阳性表达率为5%(1/20)，两组差异有统计学意义（P<0.01）（2）乳腺癌组织中的
HDAC1蛋白在ER或PR阴性乳腺癌组织中的表达分别高于其在ER或PR阳性乳腺癌组织中的表达（P<0.01）结论：乳腺癌组
织中的HDAC1蛋白过度表达与肿瘤发生发展密切相关。 |
| 英文摘要: |
| To investigate the expressions of HDAC1 protein and its clinical significance in the breast carcinoma tissue. Methods:
The expression of HDAC1 protein was determined by immunohistochemistry with SP system. Its correlation to estrogen receptor(ER)
and progesterone receptor(PR) was analyzed. Results: (1)The positive rate of HDAC1 protein was 78.2% in breast carcinoma, which was
5% in noncancerous tissue group. There were significant differences between them(P<0.01). (2)The expression of HDAC1 had negative
correlation to ER and PR. Conclusion: The overexpression of HDAC1 protein closely correlated with the tumor carcinogenesis. |
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