| 郭晓东杨永平楼敏熊璐曲建慧王春平陆荫英周霖常秀娟
苏淑慧冯永毅.凋亡诱导因子AIF在肝癌组织中的表达及临床意义*[J].现代生物医学进展英文版,2011,11(3):502-504. |
| 凋亡诱导因子AIF在肝癌组织中的表达及临床意义* |
| Expression of Apoptosis Inducing Factor in Hepatocellular Carcinoma andIts Clinical Signficance |
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| DOI： |
| 中文关键词: 肝细胞癌 凋亡诱导因子 免疫组织化学 |
| 英文关键词: Hepatocellular carcinoma, Apoptosis inducing factor,Immunohistochemistry |
| 基金项目:全军十一五基金项目（424134H） |
| Author Name | Affiliation | | GUO Xiao-dong, YANG Yong-ping, LOU Min, XIONG Lu, QU Jian-hui, WANG Chun-ping, LU Yin-ying, ZHOU Lin,
CHANG Xiu-juan, SU Shu-hui, FENG Yong-yi | 北京市解放军第302医院 |
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| 中文摘要: |
| 目的：探讨凋亡诱导因子(AIF)在肝细胞癌组织中的表达及其临床意义。方法：采用免疫组织化学Envision 法检测75例肝细
胞癌组织及其相应癌旁肝组织、30例正常肝组织中AIF的表达,并分析其表达与肝细胞癌临床病理因素的相关性。结果：肝癌组
织中AIF阳性表达率明显高于癌旁组织及正常肝组织，差异均具有统计学意义(P<0.01)。AIF在肝癌组织中的表达仅与病理分级
密切相关(P<0.01),而与年龄、性别、肿瘤大小、临床分期、肿瘤数目、有无肿瘤包膜和有无淋巴结转移、有无门静脉癌栓均无关。结
论：AIF表达可能参与了肝癌的发生和发展过程。 |
| 英文摘要: |
| Objective: To investigate the expression and clinical signficance of AIF in hepatocellular carcinoma tissue. Methods:
The expression of AIF protein was detected with immunohistochemical EnVision plus non-hiotin technique in 75 cases of hepatocellular
carcinoma and pericarcinoma tissues, 30 cases of norma1 tissues. Results: The positive expression rates of AIF protein in hepatocellular
carcinoma were significantly higher than that in pericarcinoma tissues and norma1 tissues (P<0.05). The expression of AIF were positively
related to differentiation degree (P<0.05) |
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