| 刘越男李珊珊董秀谷丽维李建春△.志贺毒素及其预防治疗剂的研究进展[J].现代生物医学进展英文版,2011,11(2):397-400. |
| 志贺毒素及其预防治疗剂的研究进展 |
| The development of study on Shiga toxin and the prevention and treatment |
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| DOI： |
| 中文关键词: 志贺毒素 溶血性尿毒综合征 产志贺毒素大肠杆菌 |
| 英文关键词: Shiga toxin HUS STEC |
| 基金项目: |
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| 中文摘要: |
| 志贺毒素（Shiga toxin,Stx）主要由肠出血性大肠杆菌（EHEC）产生，是其主要的致病毒力因子，可通过引起急性肾衰竭导致
死亡。迄今为止尚没有可推荐的治疗方案能够有效地预防或治疗Stx 引起的疾病。目前，对于Stx 的研究热点主要包括：Stx 尚未
清楚的致病机理研究，Stx 与HUS的相关性研究，以及预防、治疗由Stx 引起的疾病的研究。本文就以上几方面对国内外的相关研
究进行总结及讨论。 |
| 英文摘要: |
| Stx is a member of the family of protein toxins produced by Escherichia coli O157:H7 and other enterohaemorrhagic
E. coli. Renal disease was thought to be due to the combined action of Shiga toxin, which was the primary virulence factor of Shiga toxin.
So far, there is no effective treatment of Stx-complications. Nowadays, the focus on Stx including: the unknown nosogenesis of Stx, the
relationship between Stx and HUS, and prevention and treatment of Stx-complications. This paper will give a reviewe on important
aspects of Stx. |
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