| 李春成贺修胜王妍陈苏琼姚旭炯李丽.S100A11在结肠癌的表达及其与临床特征的关系[J].现代生物医学进展英文版,2011,11(2):338-340. |
| S100A11在结肠癌的表达及其与临床特征的关系 |
| Expression and clinical features of S100A11 in colon carcinoma tissues |
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| DOI： |
| 中文关键词: S100A11 结肠癌 RT-PCR Western Blotting |
| 英文关键词: S100A11 colon carcinoma RT-PCR Western Blot |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨S100A11 在结肠癌和正常肠粘膜组织中的表达及其与患者临床特征的的关系。方法：采用RT-PCR、Western
Blotting技术，检测S100A11 在24 例结肠癌及正常肠粘膜中的表达，并分析S100A11 与患者年龄，性别，临床病理分型之间的关
系。结果：S100A11mRNA在结肠癌组织的表达量（0.944+0.032）高于正常肠粘膜组织中的表达量（0.828+0.079），两组比较差异有
统计学意义（p＜0.05）。S100A11蛋白在结肠癌组织中的表达量（0.951+0.02）高于在正常肠粘膜组织中的表达量（0.860+0.05），两
组比较差异有统计学意义（p＜0.05）。但与患者临床特征之间比较差异无统计学意义（p＞0.05）。结论：S100A11在结肠癌组织中
表达量高于正常肠粘膜组织，提示其与结肠癌的发生和发展有关. 是判断结肠癌生物学行为的有价值的参考指标。 |
| 英文摘要: |
| Objective: To study the expression of S100A11 in normal and carcinoma colon tissues and the correlation between the
result and clinical feature. Methods: The expression of S100A11 in 24 colon carcinoma and normal colon tissue were examined by
RT-PCR and Western Blotting. The relationship between S100A11 and clinical parameters including patient's age, sex, differention degree
were analyzed. Result: Expression intensity value of S100A11 mRNA was 0.944+0.032 in human colon cancer tissues, Which of human
normal colon mucous membrane Tissue was 0.828+0.079 （p＜0.05）. Expression intensity value of S100A11 protein was
0.951+0.02 in human colon cancer tissue, Which of human normal colon mucous membrane tissue was 0.860+0.05（p＜0.05）. Results
suggest the expression of S100A11 in colon cancer tissues was higher than that in normal colon tissues. Conclusion: Expression of
S100A11 in colon cancer tissues was higher than that in normal colon tissue. Which indicates that S100A11 would play a significant role
in the tumorrigenesis and development of colon cancer, therefore,S100A11could be regarded as a valuable prediction index that aims to
judge biological behavior of colon cancer. |
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