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目的：观察新生儿缺氧缺血性脑病（hypoxic-ischemic encephalopathy ,HIE）血清S-100B 蛋白的动态变化规律，探讨其在HIE 早期诊断中的价值，以及其浓度变化与病情严重程度及预后的关系。同时研究围产期高危因素以及NBNA评分在HIE发生发展与预后中的作用。方法：30例住院正常新生儿作为对照组，于出生后采血，55例HIE患儿（HIE 组）分别于出生后1 天、2 天、7 天采血，采用酶联免疫吸附试验、双抗体夹心法检测。收集并分析两组围产期相关资料。HIE组并于采血同时进行NBNA评分。结果：（1）HIE 患儿生后第一天与第二天血清S-100B 蛋白浓度明显高于对照组（P＜0.05），生后第七天轻度HIE 与对照组比较没有统计意义，中、重度HIE与对照组比较有统计学意义。（2）生后第一天与第二天不同病情组HIE患儿NBNA评分相互比较差异具有统计学意义（P＜0.05），第七天轻、中和重度患儿NBNA评分＜35分的患儿分别占33.3%，47.1%，100%。结论：动态监测HIE患儿血清S-100B蛋白浓度和NBNA评分的变化，对HIE的早期诊断，严重程度的判断以及预后的估计有重要意义。

英文摘要:

Objectives:To investigate the clinical value of S-100B and NBNA score on neonatal with hypoxic ischemic encephalopathy (HIE) in early judgment and prognosis, and to study the clinica1 significance of perinatal stage high risk factor. Methods: 30 cases of normal neonates as control group, The serum S-100B concentrations were detected in 55 asphyxia newborn at 1st day, 2nd days and 7th days after birth. Carrying out NBNA score. at the same time. S - 100 protein was measured dynamically by ELASA. Collectting and analyzing perinatal stage correlated information. Results: (1) The levels of serum S-100B in newborns with HIE were obviously higher than that in control group at 1st day and 2nd days (P＜0.05), No significant differences were observed in the slight pathologyical change group as compared with the levels of control group at 7th days (P＞0.05). (2) To compare NBNA score in newborns with HIE , there was still significantly different between the different pathogenetic condition at 1st day and 2nd days (P＜0.05). At 7th days, NBNA score＜35 was 33.3%，47.1%，100% . Conclusion: It is important for early diagnosis and determination of the severity and prognosis of HIE to monitor serum S-100B protein levels and NBNA score.

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