| 李武谢小兵.急性脑梗死患者相关生化指标检测的临床意义[J].现代生物医学进展英文版,2011,11(2):283-286. |
| 急性脑梗死患者相关生化指标检测的临床意义 |
| Clinical significance of changes in biochemical indexes in patientswith acute cerebral infarction |
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| DOI： |
| 中文关键词: 急性脑梗死 同型半胱氨酸 C反应蛋白 内皮素－1 血栓素A2 凝血 纤溶 |
| 英文关键词: acute cerebral infarction Hcy hs-CRP ET-1 TXA2 coagulation fibrinolysis |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨急性脑梗死（ACI）患者治疗前后Hcy、ET-1、hs-CRP、TXA2水平和凝血纤溶指标的变化及临床意义。方法：分别采
用ELISA法、发色底物法、凝血酶法、放射免疫法和免疫透射比浊法对68 例ACI患者治疗前后Hcy、ET-1、hs-CRP、TXA2和各凝
血纤溶指标水平进行检测，并以30例正常健康人作为对照组。结果：① ACI患者治疗前血浆Hcy、ET-1 和血清hs-CRP、TXA2含
量高于对照组（P<0.01），经过治疗，含量均明显下降，其中血浆Hcy、ET-1 恢复至正常水平，与对照组间比较差异无统计学意义
（P>0.05）② 轻、中、重型组间血浆ET-1 和血清hs-CRP、TXA2含量逐渐增加，组间差异有显著性（P<0.01 或0.05），而中重型患者
血浆Hcy含量明显高于轻型患者（P<0.01）。③ 经过治疗，ACI患者血浆vWF、GMP-140、Fg和F1+2含量较治疗前显著下降，而血
浆PS活性、PC 活性与AT 水平较治疗前明显上升（P<0.01），其中血浆PS和PC 活性与对照组间比较差异无统计学意义（P>0.
05）。④ACI患者血浆中tPA水平低于对照组，血浆PAI-1含量高于对照组（P<0.01）。治疗后血浆tPA增加，与对照组间差异无统
计学意义（P>0.05），PAI－1减少，但仍显著高于对照组（P<0.05）。结论：检测急性脑梗死（ACI）患者Hcy、ET-1、hs-CRP、TXA2和凝
血纤溶指标水平的变化对于指导用药、病情观察和预后评估均有重要的临床意义。 |
| 英文摘要: |
| Objective: To study the significance of Hcy, ET-1, hs-CRP, TXA2, parameters of coagulation and fibrinolysis in
patients with acute cerebral infarction (ACI) before and after treatment. Methods: ELISA, chromogenic substrate assay, Clauss assay,
radioimmune and immune turbidimetric method were used to determine levels of Hcy, ET-1, hs-CRP, TXA2, parameters of coagulation
and fibrinolysis in 68 case with ACI before and after treatment, as well as in 30 control normal cases. Results: ① Before treatment, the
levels of plasma Hcy, ET-1 and serum hs-CRP, TXA2 significantly increased in patients with ACI, higher than those in control group
(P<0.01), which decreased after treatment, especially plasma Hcy and ET-1 (P>0.05). ② The levels of plasma ET-1 and serum hs-CRP,
TXA2 gradually increased from minor to severe grade (P<0.01 or 0.05), while the level of plasma Hcy in modest and severe grade was
significantly higher than minor grade (P<0.01). ③ After treatment, the levels of plasma vWF、GMP-140, Fg and F1+2 were significantly
lower than those before treatment, but plasma PS, PC and AT higher than before treatment (P<0.01), and there was no difference in levels
of PS, PA between ACI patients and control group (P>0.05). ④ The concentration of plasma tPA was significantly lower than control
group, while plasma PAI-1 higher than control before treatment (P<0.01 or 0.05). After treatment, tPA increased and PAI-1 decreased,
but the level of PAI-1 remained significantly different from control (P<0.05). Conclusion: Levels of Hcy, ET-1, hs-CRP, TXA2, parameters
of coagulation and fibrinolysis could guide drug therapy, evaluate disease severity and its prognosis in patients with ACI. |
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