| 李东升1 欧阳军1△ 赵磊2.胰岛素对大鼠肠缺血再灌注损伤的影响[J].现代生物医学进展英文版,2011,11(2):252-255. |
| 胰岛素对大鼠肠缺血再灌注损伤的影响 |
| Effect of Insulin on Gut Injury Following Intestinal Ischemia-reperfusion |
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| DOI： |
| 中文关键词: 小肠 缺血再灌注损伤 胰岛素 |
| 英文关键词: small intestine ischemia reperfusion injury insulin |
| 基金项目: |
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| 中文摘要: |
| 目的：观察胰岛素对大鼠肠缺血再灌注后小肠组织损伤的影响。方法：雄性SD大鼠40只随机分为4组，每组10只，手术对
照组、单纯缺血组、再灌注组、胰岛素干预组。于30min 缺血和120min 再灌注后，进行组织病理学和生化检测。结果：（1）单纯缺血
组肠粘膜损害较手术对照组明显升高（P＜0.01），超氧化物歧化酶（SOD）活性无明显变化；（2）再灌注组SOD 活性明显降低，与手
术对照组和单纯缺血组相比较差异均有显著性（P＜0.01）；（3）胰岛素组SOD 活性与再灌注组相比有明显改善（P＜0.01）。结论：
肠缺血可以引起肠粘膜损伤，再灌注则可加重这种损伤，胰岛素可以减轻再灌注损伤。 |
| 英文摘要: |
| Objective: To investigate the effects of insulin on gut injury following intestinal ischemia-reperfusion (I/R). Methods:
Forty male SD rats were randomly divided into 4 groups ,n=10 in each group: (1)control group,(2)simple ischemia group,(3)re-perfusion
group, (4)insulin group. Results: (1) Mucosal injury score were significantly higher in the simple ischemia group than the control group
（P＜0.01）, the SOD activities have no evident change;(2)The SOD activities of the re-perfusion group were significantly decreased compared
to the control group and simple ischemia group（P＜0.01）;(3)The SOD activities in the insulin group were significantly higher
compared to the reperfusion group（P＜0.01）. Conclusion: Intestinal ischemia can damage the intestinal mucosa in rats. Reperfusion can
lead to further injury.Insulin can attenuate the mucosa damage. |
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