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目的：探讨小檗碱对动脉粥样硬化损伤的保护作用。方法：将56只大鼠，随机分为对照组（C），高脂饮食假手术组(HD)，肾动脉狭窄组(RAS)，肾动脉狭窄高脂饮食组(HD+RAS)。C 及RAS 组给予正常饮食，HD 及HD+RAS 组给予高脂饮食，RAS 及 HD+RAS组采用固定内径银夹夹左肾动脉。饲养12周，每组处死6只进行检测，剩余除C外每日灌胃小檗碱（150mg/kg），C予以等量生理盐水灌服，持续4 周，四周后处死进行相同检测，用药前后结果进行对比评价小檗碱功能。结果：与C 相比，HD，RAS， HD+RAS组肌酐显著升高（P<0.05），HD及HD+RAS组胆固醇明显升高（P<0.05），超氧化物歧化酶(SOD)在HD,RAS及HD+RAS 组显著降低（P<0.05），丙二醛(MDA)在HD,RAS 及HD+RAS 组显著增高（P<0.05），血管内皮生长因子VEGF 在HC,RAS 及 HD+RAS组表达量升高。给予小檗碱灌胃处理后，检测指标各组间无统计学差异（P>0.05）。结论：小檗碱对动脉粥样硬化性损伤具有良好的保护作用。

英文摘要:

Objective: To investigate the protect effect of Berberine on atherosclerotic injury. Methods: Fifty-six rats were randomly divided into control group (C),high-fat diet group (HD),renal artery stenosis group (RAS), high-fat diet with renal artery stenosis group (HD+RAS), fourteen in each group.C and RAS were given proper diet, HD and HD+RAS were given high fat diet. RAS and HD+RAS were clamped by sliver clip with a fixed diameter on left renal artery. 12 weeks later, executed six of every group for testing, the left were given Berberine (150mg/kg) every day except C,C were given saline .4 weeks later, the left rats were executed for the same testing. Results: Compared with C, Creatinine was significantly higher in other three groups(p<0.05). Cholesterol was significantly higher in HD and HD+RAS groups (p<0.05).SOD was Significantly higher while MDA was Significantly lower in HD, RAS and HD+RAS group. The ex- pression of VEGF was significantly higher in HD,RAS and HD+RAS group. After given berberine，the testing results had no significant difference in different groups. Conclusions: Berberine has good protection effect on atherosclerotic injury.

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