| 姚亚丽李昌琪△.早期负性经历的表观遗传学研究进展[J].现代生物医学进展英文版,2011,11(1):161-164. |
| 早期负性经历的表观遗传学研究进展 |
| The Progress of Epigenetics in Early Adverse Experiences |
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| DOI： |
| 中文关键词: 负性经历 表观遗传 个体行为 |
| 英文关键词: Adverse experience Epigenetics Individual behavior |
| 基金项目:国家自然科学基金项目（302001098） |
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| 中文摘要: |
| 表观遗传学(epigenetics)是指不涉及DNA 序列改变、可以通过有丝分裂和减数分裂进行遗传的基因表达变化的遗传学分支
领域。目前研究主要集中在DNA 甲基化、组蛋白密码、染色质重塑和非编码RNA 调控等方面。早期负性经历是指个体出生早年
所经历的不良生活事件，还包括个体出生前所经历的负性生活事件。大量研究表明早期负性经历对个体成年后的行为会造成明
显影响。本文将综述早期负性经历中表观遗传的各种机制。 |
| 英文摘要: |
| Epigenetics is a branch of genetics ,with no changes of DNA sequence, the genetic expression changes are through
mitosis and meiosis. Current researches are focused on DNA methylation, histone code, chromatin remodeling and regulation of non-coding
RNA and so on. Early adverse experiences points to negative life events experienced by an individual in the early years after born, it also
includes before born. Numerous studies show that Early adverse experiences will affect the adult behaviors of individuals. This paper will
survey all kinds of epigenetic mechanisms in the early negative experiences. |
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