| 张立国1 杨天明1△ 钱志余2 潇笛2 郭凯1 刘华亭1.近红外光谱技术在猫脑射频热凝毁损中的应用研究[J].现代生物医学进展英文版,2011,11(1):71-74. |
| 近红外光谱技术在猫脑射频热凝毁损中的应用研究 |
| Application of near-infrared spectroscopy technology in cat brainradiofrequency |
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| DOI： |
| 中文关键词: 近红外光谱技术 优化散射系数 立体定位技术 猫脑 |
| 英文关键词: Near-infra red spectroscopy Reduced scattering coefficient Stereotactic technology Cats |
| 基金项目:国家高技术研究863 计划基金资助(2008AA02Z438) |
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| 中文摘要: |
| 目的：探索近红外光谱(nears)技术用于立体定向靶点毁损术中实时监测的可行性。方法：利用猫脑建立体内不同毁损时间、
温度下的毁损灶体积模型，通过病理检测及近红外光谱仪观察并记录脑组织靶点毁损时的NIRS 尤其是优化散射系数（）的变化
情况。结果：不同温度、不同时间温度点下NIRS 出现特征性变化曲线。并建立时间、温度及三维模型。结论：利用NIRS 实时活体
在位监测猫脑射频神经核团毁损术是科学、可行的,优化散射系数是监测的良好指标，比以往单凭经验的作法更科学、更准确。 |
| 英文摘要: |
| Objective: To investigate the feasibility of near-infrared spectroscopy (NIRS) technology i monitor real-time target in
the stereotactic destruction technology. Methods: In vivo volume models of RF lesion with different lesion time and temperature were established
(,adult cats in vivo ). The height and maximum lesion diameter of adult cats in vivo were detected by pathology testing and
MRI. Target destruction in near-infrared spectroscopy monitoring: Changes in brain tissue, the changes of reduced scattering coefficient
in particular, were detected by brain tissue spectroscopy. Results: Under the same lesion conditions, there was significant difference between
the volume of in vivo (p<0.05), the volume which obtained frome in vivo was alerted regularly by the changes of the lesion time
and lesion temperature. Conclusion: Real-time near infrared technology in vivo to monitor RF power in damaged nucleus of cats was scientific
and feasible. In addition, the reduced scattering coefficient was good indicator for monitoring. |
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