| 颜冬菁黄欣媛冷明垒陈正望陆婕.性别与自身免疫性疾病[J].现代生物医学进展英文版,2011,11(13):2562-2564. |
| 性别与自身免疫性疾病 |
| Sex and Autoimmune Disease |
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| DOI： |
| 中文关键词: 自身免疫性疾病 性别差异 雌激素 微嵌合体 性染色体 |
| 英文关键词: Autoimmune diseases Sex bias Estrogen Microchimerism Sex chromosome |
| 基金项目:湖北省自然科学基金（2009CDB076）；中央高校基本科研业务费资助，HUST：(2010MS009) |
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| 中文摘要: |
| 自身免疫性疾病在人群中感染率5-10%，具有明显的性别差异，女性患者显著高于男性，具体机制仍未研究清楚。研究发现，
除了机体自身的遗传易感体质外，雌激素，微嵌合体和性染色体都与自身免疫性疾病发病有关。 |
| 英文摘要: |
| Autoimmune diseases are estimated to affect 5-10% of the population with a significant female predominance
reported for most of them. The mechanism of this sex bias remains unclear. Including a susceptible genetic background, autoimmune
diseases are expected to be associated with estrogen, microchimerism and sex chromosome. |
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