| 潘育方1 邹 燕2.珍芪降糖胶囊对糖尿病大鼠的药效学研究[J].现代生物医学进展英文版,2006,6(8):42-43. |
| 珍芪降糖胶囊对糖尿病大鼠的药效学研究 |
| Study on pharmacodynamics effect of ZhenQijiangtang Capsule on diabetic rats |
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| DOI： |
| 中文关键词: 珍芪降糖胶囊 糖尿病大鼠模型 血糖 肌酐 血小板聚集 |
| 英文关键词: ZhenQijiangtang Capsule Diabetic rats Blood glucose Creatinine Platelet aggregation |
| 基金项目: |
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| 中文摘要: |
| 目的:研究珍芪降糖胶囊对实验性糖尿病大鼠的治疗效果。方法:采用腹腔注射链脲佐菌素(STZ)制备糖尿病大鼠模
型, 观察珍芪降糖胶囊对大鼠血糖、胰岛素、血脂、尿素氮、肌酐、血小板聚集及肾小球形态的影响。结果:珍芪降糖胶囊能明显降
低糖尿病大鼠的血糖、胰岛素含量, 降低糖尿病大鼠低密度脂蛋白胆固醇、尿素氮、肌酐, 提高高密度脂蛋白胆固醇含量, 对二磷
酸腺苷(ADP)诱导的大鼠血小板聚集有明显的抑制作用, 并有减轻肾小球病变的作用。结论:珍芪降糖胶囊在降低血糖、调节脂
质代谢紊乱、改善肾小球功能等多方面发挥较好的作用。 |
| 英文摘要: |
| Objective :To study the therapeutic effect of ZhenQijiangtang Capsule on the diabetic rats .Methods:The models of 40 mice
with diabetes were made by injecting Streptozotocin(STZ), the effect of ZhenQijiangtang Capsule on the blood glucose , insulin, blood fat , bun ,
creatinine , platelet aggregation(PA)and glomerular morphology of the mice were observed.Results:ZhenQijiangtang Capsule can obviously reduce
the mouse' s blood glucose , insulin and Low Density Lipoprotein Cholesterol)(LDL-c), bun, creatinine , improve high-density Lipoprotein
cholesterol (HDL-C), restrain platelet aggregation caused by adenosine diphosphate (ADP), and lighten pathological changes of glomerulosclerosis.
Conclusion:ZhenQijiangtang Capsule does better function in many ways , such as reducing blood glucose , adjusting lipid metabolic
disturbance , and improving the function of glomerulosclerosis. |
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