| 张巨峰1 周立社2 彭志平3 秦文斌2 雎天林2.GSTT1 、GSTM1 基因多态性与重度慢性牙周炎
易感性关系的研究[J].现代生物医学进展英文版,2006,6(8):28-30. |
| GSTT1 、GSTM1 基因多态性与重度慢性牙周炎
易感性关系的研究 |
| Study on Relationship between Polymorphisms of GSTT1 and GSTM1genes and susceptibility to severe chronic periodontitis |
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| DOI： |
| 中文关键词: 慢性牙周炎 基因多态性 GSTT1 基因 GSTM1 基因 易感性 |
| 英文关键词: Gene polymorphisms GSTT1 gene GSTM1 gene Susceptibility Chronic periodontitis |
| 基金项目: |
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| 中文摘要: |
| 目的:研究GSTT1+/0 和GSTM1 +/0 基因型及其联合基因型与重度慢性牙周炎(chronic periodontitis, CP)易感性的关
系。方法:用聚合酶链反应检测50 例重度慢性牙周炎患者和51 例正常对照者的GSTT1+/ 0、GSTM1+/0 的基因型。结果:GSTM1
(0/0)和GSTT1(0/ 0)基因型及GSTM1(0/0)与GSTT1(0/ 0)联合基因型对重度慢性牙周炎相对危险度(OR)分别为9.56(95 %CI , 3 .
88 -23.59), 8 .68(95 %CI , 3.50-21.51), 36 .83(95%CI , 10 .42-130.13)。结论:在内蒙古汉族人群中, 基因型GSTT1(0/ 0)和GSTM1
(0/0)增加了个体对重度慢性牙周炎易感性, 且上述两种基因型间存在协同作用。 |
| 英文摘要: |
| Objective :To investigate the polymorphisms of GSTT1 and GSTM1 genes as well as their separate and combined effects on
susceptibility to severe chronic periodontitis.Methods:In the 50 patients with chronic severe periodontitis and 51 healthy controls, the genotypes
of GSTT1+/0 and GSTM1+/ 0 polymorphisms were detected by PCR.Results:Individuals with genotype(0/ 0)of GSTM1, genotype(0/ 0)of
GSTT1, combined genotypes GSTM1(0/ 0)and GSTT1(0/ 0)had more relative risks than those with the corresponding common genotypes, whose
ratios were 9.56(95%CI3.88 -23.59), 8 .68(95 %CI3.50-21 .51), 36.83(95%CI 10.42-130 .13).Conclusion:There is a synergy of
susceptible genotypes GSTM1(0/0)and GSTT1(0/ 0)to enhance the individual susceptibility to chronic severe periodontitis . |
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