| 吴 梅1 韦程纲1 阴 骏1 刘伟锋1 曲丽英2 郭启勇3 王海林1.鼻咽癌CT 表现与p53 、p16 蛋白异常表达关系的研究[J].现代生物医学进展英文版,2006,6(8):15-18. |
| 鼻咽癌CT 表现与p53 、p16 蛋白异常表达关系的研究 |
| Relationship between CT Findings and p53 and p16 ProteinAabnormal Expression of Nasopharyngeal Carcinoma |
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| DOI： |
| 中文关键词: 鼻咽癌 CT p53 蛋白 p16 蛋白 免疫组化 |
| 英文关键词: Nasopharyngeal carcinoma Tomography , X-ray computed p53 protein p16 protein Immunohistochemistry |
| 基金项目: |
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| 中文摘要: |
| 目的:研究p53 、p16 蛋白表达与鼻咽癌CT 表现的关系。方法:经病理证实鼻咽癌50 例, 全部病例做鼻咽轴位平扫, 部
分病例同时做冠状扫描。应用免疫组化SABC 法检测所有病例中的p53 、p16 蛋白的表达。结果:鼻咽癌及鼻咽粘膜慢性炎症中
p53 蛋白表达率分别为60%和10%, p16 蛋白表达率分别为32 %和85%, p53 、p16 表达在两者间的差异有极显著意义(P<0 .005)。
p53 蛋白表达与鼻咽癌分化程度及CT 表现为副鼻窦受累, 颅底骨质破坏相关(P<0 .05)。p16 蛋白表达与鼻咽癌预后及CT 表现
为颈部淋巴结转移相关(P<0.05)。p53 与p16 有相关性(P<0.005)。结论:p53、p16 在鼻咽发生、发展中起重要作用, p53 蛋白表
达与鼻咽癌分化程度、浸润深度、颅底侵犯有一定相关性, p16 蛋白表达与鼻咽癌颈部淋巴结转移和预后有一定相关性, p53、p16
可作为评价鼻咽癌CT 表现恶性度及预后的指标。 |
| 英文摘要: |
| Objective :To study the relationship between the expression of p53 and p16 protein and CT findings of nasopharyngeal carcinoma(
NPC).Mathods :50 patients of NPC were confirmed by biopsy .Axial CT plain scans in all cases, using 6～ 8mm axial scans with 6～ 8 mm
spacing , and coronary slice scaning in some cases were performed.And all cases were examined for expression of p53 and p16 protein by immunohistochemical
method .Results:1.The positive expression of p53 and p16 in nasopharyngeal carcinoma and chronic nasopharyngeal mucosa
inflammation were 60%(30/50), 32 %(16/ 50), 10%(2/20), 85 %(17/20).The difference between p53 and p16 expression was significant
(p<0.005).2.p53 protein expression was correlated with histodifferentiation (p<0 .05), tumors with undifferentiated cell had strong p53 abnormal
expression.3 .No significant difference was found among clinical stages for p53 , p16 protein expression.4.p16 protein expression was
correlated with prognosis and cervical lumph node metastasis (p <0 .05).5.p53 protein expression was correlated with accessory nasal sinuses
involvement and skull base destruction (p<0.05).6 .Relationship was found between p53 and p16 gene expression(p<0.005).Conclusion:
p53 and p16 might play an important role in the pathegesis and development of nasopharyngeal carcinoma .p53 protein expression was correlated
with histodifferentiation, invasive depth and skull base destruction ;p16 protein expression , prognosis and cervical lumphnode metastasis.p16 and
p53 could be served as indicator for predicting prognosis and malignancy of CT findings of nasopharyngeal carcinoma . |
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