| 徐广贤 赵德明.牛分支杆菌与肺结核分支杆菌基因组的比较[J].现代生物医学进展英文版,2006,6(7):67-69. |
| 牛分支杆菌与肺结核分支杆菌基因组的比较 |
| Comparision of genome between Mycobacterium bovis and Mycobacterium tuberculosis |
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| DOI： |
| 中文关键词: 牛分支杆菌 肺结核分支杆菌 比较基因组学 单核苷酸多态性( SNPs) |
| 英文关键词: Mycobacterium bovis Mycobacterium tuberculosis Comparative genomics Single- nucleotide polymorphism ( SNPs) |
| 基金项目:教育部高等学校博士学科点专项科研基金( 项目编号: 20050019031) 资助 |
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| 中文摘要: |
| 通过比较基因组学的方法研究发现, 牛分支杆菌与肺结核杆菌基因组的同源性为99. 95%, 但在牛分枝杆菌基因组中
有11 个缺失区, 大小从1kb 到12. 7kb, 遗传信息的缺失引起牛分枝杆菌的基因组减小; 牛分枝杆菌与肺结核分枝杆菌H37Rv 间
存在着2437 个单核苷酸多态性( SNPs) , 与肺结核分枝杆菌CDC1551 间存在着2423 个单核苷酸多态性( SNPs) , 牛分支杆菌与肺结
核分枝杆菌在编码细胞壁和分泌蛋白上变异程度也是巨大的。研究结果揭示了牛分支杆菌与肺结核分枝杆菌的遗传关系, 为研
究分支杆菌疫苗和诊断试剂提供理论依据, 对牛肺结核病的防治有着非常重要的意义。 |
| 英文摘要: |
| Through the comparision of genome between the Mycobacterium bovis andMycobacterium tuberculosis, it is concluded that
the homology ofMycobacterium bovis andMycobacterium tuberculosis are 99. 95% respectively, but there are 11 deletants( range, from 1kb to 12.
7kb in the genome of the Mycobacterium bovis. The absence of genetic information resulted in reduction of genome inMycobacter ium bovis. There
are 2437 single- nucleotide polymorphisms ( SNPs) between the Mycobacterium bovis and Mycobacterium tuberculosis H37Rv, 2423 SNPs, between
the Mycobacterium bovis andMycobacter ium tuberculosisCDC1551. The extent of variation is obvious on Codocyte cellwall and secreted protein
between the two. The finding reveals the genetic relationship between Mycobacterium bovis and Mycobacterium tuberculosis, which offers a
theoretical basis for Mycobacterium vaccine and diagnostic reagent, and is of great significance for the prevention and treatment of Bovine pu-l
monary tuberculosis. |
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