| 钟 萍1 吴丹红2.腹腔注射LPS 对大鼠海马nNOS 和iNOS 表达的影响[J].现代生物医学进展英文版,2006,6(7):29-30. |
| 腹腔注射LPS 对大鼠海马nNOS 和iNOS 表达的影响 |
| Effects of intraperitoneal injection of LPS on expression of nNOS and iNOS in rats hippocampus |
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| DOI： |
| 中文关键词: / 海马0 / 一氧化氮合酶0 / 细菌脂多糖0 |
| 英文关键词: / LPS0 / hipcampus0 / NOS0 |
| 基金项目: |
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| 中文摘要: |
| 目的: 探讨外周免疫刺激对大鼠海马nNOS 和iNOS 表达的影响。方法: 腹腔注射LPS 600Lg / kg 建立免疫激发大鼠模
型, 对照组注射等量的生理盐水, 2. 5h 后用RT- PCR 技术, 观察两组大鼠海马nNOS mRNA 和iNOS mRNA 的表达变化, 检测OD 值
并进行统计学分析。结果: 腹腔注射LPS 组大鼠海马的nNOS 和iNOS 的mRNA 水平较对照组高。结论: 海马在大鼠机体的免疫
应激反应中起重要调节作用, iNOS 和nNOS 来源的NO 是该调节过程中的重要信使分子。 |
| 英文摘要: |
| Objective: To investigate the effects of peripheral immune stimulation on expression of nNOS and iNOS in rats hippocampus.
Methods: Rats of experiment group were intraperitoneally injected LPS, control rats were treated by saline. 2. 5h after treatment, RTPCR
was used to observe the expression of nNOS mRNA and iNOS mRNA. After their OD value was detected, we make statistic analyses. Results:
The level of nNOS mRNA and iNOS mRNA in LPS treated rats hippocampus were increased more obviously than that in control rats.
Conclusion: Rats Hippocampus plays an important role in its immunomodulation process in which NO made by nNOS and iNOS acts as one of
important signal molecules. |
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