| 田大丰1 李 英1 莫凤奎1 俞红凯2 王中彦1.辛伐他汀自微乳化胶囊的体内评价[J].现代生物医学进展英文版,2006,6(7):27-28. |
| 辛伐他汀自微乳化胶囊的体内评价 |
| Assessment of simvastatin with a self- emulsifying capsule in vivo |
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| DOI： |
| 中文关键词: 辛伐他汀 自微乳化 胶囊 HPLC 生物利用度 |
| 英文关键词: Simvastatin Self- microemulsifying Capsule HPLC Bioavailability |
| 基金项目: |
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| 中文摘要: |
| 目的: 研究辛伐他汀( SV) 自微乳化胶囊在比格犬体内的药代动力学。方法: 采用HPLC 法测定比格犬血浆药物浓度,
与市售片比较, 考察SV 自微乳化胶囊的体内药代动力学。结果: 药代动力学测定结果表明: 与市售片比较, 自微乳化胶囊血药浓
度达峰时间提前、最高血药浓度增大, Tmax = 1. 41h, Cmax= 46. 22ng??mL- 1, 而市售片的Tmax= 2. 65h, Cmax = 12. 43ng??mL- 1; AUC0- ?? 为
市售片剂的227. 5%。结论: 自微乳化胶囊可以显著提高SV 的体内吸收。 |
| 英文摘要: |
| Objective: To evluate the self- microemulsifying ablity and dissolution behavior of simvastatin in vitro and the pharmacokinetic
behavior in beagle dogs. Methods: The plasma concentrations were evaluated by HPLC and dissolution and pharmacokinetic behavior
of self- microemulsifying formulations were evaluated by comparison with commercial tablets. Results: The area under the curve ( AUC) was
significantly higher in the simvastatin self- microemulsifying capsules group than that in the commercial tablets group. Also, Tmax was smaller and
Cmax was much higher in the simvastatin self- microemulsifying capsules group compared with market products. Conclusion: The self - m-i
croemulsifying capsule can increase absorption in vivo significantly . |
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