| 刘 欣1 贾广义1 闫景龙2.硫酸钙作为微小颗粒骨载体的实验研究[J].现代生物医学进展英文版,2006,6(6):39-40. |
| 硫酸钙作为微小颗粒骨载体的实验研究 |
| Study on calcium sulphate as the carrier of the autogenousmicromorselized bone |
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| DOI： |
| 中文关键词: 颗粒骨 硫酸钙 载体 |
| 英文关键词: Autogenous micromorselized bone Calcium sulphate Carrier |
| 基金项目: |
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| 中文摘要: |
| 目的: 研究硫酸钙作为微小颗粒骨载体, 解决微小颗粒骨的自身缺点的实际效果, 为其临床应用提供依据。方法: 将
49 只日本大耳白兔随机分成4 组并通过手术造成双侧桡骨中段1. 5cm 骨缺损, 以植入硫酸钙为载体的自体微小颗粒骨为实验
组, 同时设立单纯植入自体微小颗粒骨, 单纯植入硫酸钙和不植入任何物质的空白对照组。术后4 周和8 周分别行大体观察, X
线摄片, 组织学观察, 骨生物力学测定。结果: 以硫酸钙为载体的自体微小颗粒骨组比单纯自体微小颗粒骨组及单纯硫酸钙组能
更有效地修复骨缺损, 单纯颗粒骨组成骨效果优于单纯硫酸钙组。空白组无骨愈合迹象; 组织学观察示以硫酸钙为载体的自体
微小颗粒骨实验组的成骨效果最好, 单纯自体微小颗粒骨组次之; 生物力学测定证明以硫酸钙为载体的自体微小颗粒骨实验组
的力学强度优于单纯自体微小颗粒骨组及单纯硫酸钙组。结论: 硫酸钙是微小颗粒骨的优良载体, 以硫酸钙为载体的自体微小
颗粒骨成骨速度快, 成骨量多, 质量高, 骨的机械强度高, 修复骨缺损的能力较单纯应用微小颗粒骨和硫酸钙强; 二者结合可充分
发辉各自的优势。 |
| 英文摘要: |
| Objective: To probe the ability of the calcium sulphate as the carrier of the autogenous micromorselized bone, to solve
the defects of micromorselized bone, and to provide the proof for the clinic. Methods: The animal models of bilateral radius bone defect were
created by surgery in Japan white big ear rabbits, the experimental group was implanted the autogenous micromorselized bonewhose carrier is ca-l
cium sulphate, while in the control groups, some was implanted the autogenous micromorselized bone, somewas implanted the calcium sulphate,
and others was implanted nothing. The bone defect were observed by gross examination, X- ray examination, histopatholgical examination and
biomechanics. determination at 4, 8W. Results: The experimental group repaired the bone defect more effectually than the control group. In the
control group, autogenous micromorselized bone did better than calcium sulphate and there is no phenomenon of healing in the group implanted
nothing. The quality and rate of the new formation bone in the examination group was the best. The effect of biomechanics in the examination
group was statistically significant different with the group implanted the autogenous micromorselized and the group implanted the calcium sulphate.
Conclusion: The calcium sulphate is the good carrier of the autogenous micromorselized bone. The autogenous micromorselized bone carried by
calcium sulphate forms more bone, whose quality, rate and biomechanics is excellent, and has more ability of repairing the bone defect than the
group implanted the autogenous micromorselized bone or calcium sulphate. |
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