| 姜法铭1 缪德年2 崔 立1.RNA 干扰技术抑制病毒复制的研究进展[J].现代生物医学进展英文版,2006,6(5):44-46. |
| RNA 干扰技术抑制病毒复制的研究进展 |
| Advances in the Inhibition of Viral Replication by RNA Interference |
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| DOI： |
| 中文关键词: RNA 干扰 dsRNA 抑制病毒复制 抗病毒治疗 |
| 英文关键词: RNAi dsRNA inhibition of virus replication antiviral therapeutics |
| 基金项目: |
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| 中文摘要: |
| RNA 干扰是指dsRNA 抑制细胞内同源基因表达的现象, RNA 干扰现象自发现以来在短短的几年里, 已成功地用于不
同种属的生物研究。dsRNA 不仅参与内源基因表达调控, 而且能够抑制宿主内病原微生物基因的表达, 参与构筑生物体的防御
机制。近年来, 运用RNAi 技术在哺乳动物中的研究不断深入, 尤其是抑制病毒复制的研究成果令人欣喜, 这为人类动物抗病毒
治疗提供了新的思路。 |
| 英文摘要: |
| RNA interference refers to the inhibition of gene expression by dsRNA. The RNA interference technique has already used
to the dissimilarity kinds of creature researches successfully in very short years. DsRNA can not only participate in gene regulation, but also inhibit
gene expression of pathogenic microbes. RNAi is believed to function as a defense against viruses. Recently, inhibition of virus replication by
means of induced RNAi has been reported for many human and animal pathogens. It makes possible the development of RNAi- based antiviral
therapeutics. In this article, we review the current researches on RNAi- mediated inhibition of virus replication. |
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