| 邹继华 宋印利.血管内皮生长因子( VEGF) 在大肠癌中的表达及临床意义[J].现代生物医学进展英文版,2006,6(5):36-37. |
| 血管内皮生长因子( VEGF) 在大肠癌中的表达及临床意义 |
| Expression of VEGF in colorectal cancer and its clinical significance |
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| DOI： |
| 中文关键词: 大肠癌 血管内皮生长因子 免疫组织化学 |
| 英文关键词: Colorectal cancer VEGF Immunohistochemistry |
| 基金项目: |
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| 中文摘要: |
| 目的: 探讨VEGF( Vascular endothelial growth factor) 在大肠癌中的表达及与肿瘤大小、病理分级、临床分期和预后的关
系。方法: 大肠癌组织蜡块50 例、癌旁组织20 例、正常组织20 例。采用免疫组化S- P 法对标本切片进行染色。结果: VEGF 在
癌组织中表达明显高于癌旁组织和正常组织, 三者之间差异显著( P< 0. 05) 。VEGF 抗原表达与病理分级、Dukes 分期呈负相关性
( P< 0. 01) 。结论: VEGF 与大肠癌的发生有关, VEGF 的检测可作为大肠癌预后评估的客观指标。 |
| 英文摘要: |
| Objective: To investigate expression of VEGF in colorectal cancer and its clinical significance. Methods: Immunohistochemical
staining S- P method was used to detect VEGF expression in normal mucous tissue ( NMT) ( 20 cases) , in the tissue adjacent to tumor
( TAT) ( 20cases) and in the colorectal cancer tissue( CCT) ( 50cases) . Results: VEGF level in CCT was much higher than those in NMT and in
TAT. There was significant difference between the three( P< 0. 05) . There was negative correlation between VEGF expression and pathological
grading and Dukes stage( P< 0. 01) . Conclusion: VEGF is associated with the growth of the colorectal cancer. VEGF could be considered as
an objective predictable index for prognosis of colorectal cancer . |
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