| 徐勇刚1 王 杰2.创伤后多脏器功能衰竭患者白细胞流变性
和细胞粘附分子水平的变化[J].现代生物医学进展英文版,2006,6(5):30-31. |
| 创伤后多脏器功能衰竭患者白细胞流变性
和细胞粘附分子水平的变化 |
| Changes of leukocyte rheological characteristic and celladhesion molecule in patients with MOF after severe trauma |
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| DOI： |
| 中文关键词: 多器官功能衰竭 创伤和损伤 白细胞 细胞粘附 |
| 英文关键词: Multiple organ failure Wounds and injuries Leukocytes Cell adhesion |
| 基金项目: |
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| 中文摘要: |
| 目的: 探讨创伤后多器官功能衰竭(MOF) 患者白细胞流变性和细胞粘附分子( CAMs) 水平的变化。方法: 采用DXC-
300A 型核孔膜红细胞变形能力测定仪、JYJ- ó 型体外血栓血小板粘附两用仪、酶联免疫吸附法( ELISA) , 分别检测了36 例创伤
后MOF 患者、31 例创伤患者和35 例健康人外周血液白细胞变形能力( LD) 、白细胞粘附功能( LAF) 、白细胞CD18 表达、血浆可溶
性细胞间粘附分子- 1( sICAM- 1) 和可溶性血管细胞间粘附分子- 1( sVCAM- 1) 的变化。结果: MOF 患者白细胞滤过指数( LFI) 、
白细胞粘附率( LAR) 、白细胞CD180 表达、s ICAM- 1, sVCAM- 1 均明显增高, 与对照组和创伤组比较差异有极显著性( F= 68. 45~
116. 20, q= 12. 161~ 21. 374, P< 0. 001) , MOF 组死亡者各指标变化较存活者更明显( t = 6. 920~ 11. 665, P< 0. 001) 。MOF 患者
LFI 和LAR 与sICAM- 1, sVCAM- 1 和白细胞CD18 表达呈正相关( r= 0. 691~ 0. 844, P< 0. 001) , LFI 与LAR 呈正相关( r= 0. 771,
P< 0. 001) 。结论: 白细胞流变性和CAMs 水平异常参与了MOF 的发生, 且与病情严重程度有密切关系。 |
| 英文摘要: |
| Objective: To explore the changes of leukocyte rheological characteristic and cell adhesion molecule in patients with mu-l
tiple organ failure(MOF) after severe trauma. Methods: By using the erythrocyte deformability apparatus, platelet and thrombus adhesion dual
- purpose apparatus and enzyme- linked immunosorbent assay ( ELISA) , we measured the leukocyte deformability ( LD) , leukocyte adhesion
function( LAF) , leukocyte CD18 expression, soluble intercellular adhesion molecule- 1( sICAM- 1) and soluble vascular cell adhesion molecule
( sVCAM- 1) concentration in 36 MOF patients, 31 trauma patients, and 35 healthy controls. Results: The leukocyte filtration index( LFI) ,
leukocyte adhesion rate( LAR) , leukocyte CD18 expression, and sICAM- 1 and sVCAM- 1 concentration were significantly higher in MOF patients
than in controls and trauma patients( F= 68. 45- 116. 20, q= 12. 161- 21. 374, P< 0. 00= , and the changes of these indicators in MOF
deaths were more obvious than those inMOF survivors( t= 6. 920- 11. 665, P< 0. 00= . The LFI and LAR inMOF patients were positively related
to leukocyte CD18 expression, sICAM- 1, and sVCAM- 1 concentration( r= 0. 691- 0. 844, P< 0. 001= ; LFI was positively related to
LAR( r= 0. 771, P< 0. 001= . Conclusion: The abnormalities of leukocyte rheologic characteristic and CAMs might be closely related to the
occurrence of MOF and the severeness of pathologic changes. |
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