| 宋立华 端 青.呼肠病毒基因组片段S1 编码蛋白的研究进展[J].现代生物医学进展英文版,2006,6(3):33-35. |
| 呼肠病毒基因组片段S1 编码蛋白的研究进展 |
| Research Progress of Proteins Encoded by Reovirus S1 Genome Segment |
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| DOI： |
| 中文关键词: 呼肠病毒 sigma1 蛋白 sigma1s 蛋白 |
| 英文关键词: Reovirus Sigma1 protein Sigma1s protein |
| 基金项目:国家自然科学基金资助项目(No .30471555);军事医学科学院创新启动基金项目(No .200408183) |
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| 中文摘要: |
| 呼肠病毒共有3 个血清型, 不同型之间S1 片段编码蛋白的同源性小于26 %, 其它9 个片段编码蛋白的同源性都
在86 %以上。S1 片段是双顺反子, 编码σ1 和σ1s, 这两个蛋白决定了呼肠病毒的感染性、致病性和毒力。本文综述了σ1、σ1s 的结
构与功能的研究进展。 |
| 英文摘要: |
| Reovirus includes 3 serotypes.Homology of proteins encoded by S1 genome segment was less than 26 % between
serotypes , while that of viral proteins encoded by other 9 segments was all more than 86%.Reovirus infectivity and pathogenicity were determined
by σ1 and σ1s encoded by segment S1.Structure and function of the two proteins were also reviewed in this paper . |
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