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目的: 研究基质金属蛋白酶- 9( matrix metalloproteinase- 9, MMP- 9) 及其组织抑制因子- 1( tissue inhibitor of metalloproteinase- 1, TIMP- 1) 在进展期胃癌中的表达情况, 探讨二者的表达与胃癌侵袭转移间的关系及二者间的联系。方法: 应用免疫组化方法检测70 例进展期胃癌标本中MMP- 9, TIMP- 1 的表达, 并进行回顾性随访。结果: 侵及肌层以上者MMP- 9 的阳性表达( 66. 67%) 明显高于肿瘤局限于粘膜、粘膜下者( 20% P< 0. 01) 。MMP- 9 阳性表达与胃癌的淋巴转移与肝转移有相关性( P< 0. 01) 。TIMP- 1 的表达随胃癌浸润深度增加而减少, 当肿瘤突破浆膜时TIMP- 1 的表达呈现陡降趋势( P< 0. 01) 。结论: MMP- 9 的过阳性表达和TIMP- 1 的表达失衡可能与胃癌转移行为有关。TIMP- 1 可能抑制胃癌的浸润转移。

英文摘要:

Objective: To study the expressions of Matr ix Metalloproteinase- 9 (MMP- 9) and Tissue Inhibitor of Metalloproteinase - 1(TIMP- 1) in progressive gastric cancer( PGC) , including the correlation between the MMP- 9 and TIMP- 1 and invasion metastasis of gastric cancer. Methods: The expressions of MMP- 9 and TIMP- 1 in 70 specimens with PGC were determined by immunohistochemistry method. The patients with PGC were retrospectively followed up. Results: Positive expression( 66. 67%) of MMP- 9 in the patients with tumor invading into or over muscular layer was significantly higher than that( 20%) of the patients with tumor in the mucous membrane or submucous tumor( p< 0. 01) . The positive expression of MMP- 9 was relative to lymphnode and hepatic metastasis( P< 0. 01) . The expression of TIMP- 1 lowered with the increasing depth of gastric cancer infiltration, which suddenly lowered when tumor broke through the serous membrane( P< 0. 01) . Conclusion: The over positive expression of MMP- 9 and expression disbalance of TIMP- 1 may be relative to gastric cancer metastasis; TIMP- 1 may inhibit infiltrating metastasis of gastric cancer.

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