| 王沧恺1 宋进毅1 王建红2, 3 马原野2.磁场对小鼠两种迷宫学习记忆的影响[J].现代生物医学进展英文版,2006,6(3):11-14. |
| 磁场对小鼠两种迷宫学习记忆的影响 |
| Effects of low frequency magnetic field on mice learningand memory in Y- maze and Morris water maze |
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| DOI： |
| 中文关键词: 磁场 学习记忆 旷场 Morris 水迷宫 Y- 迷宫 |
| 英文关键词: Magnetic field Memory Open- field Morris water maze Y- maze |
| 基金项目:国家自然科学基金项目资助(No. 30470553) , (No. 30530270) |
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| 中文摘要: |
| 据发现, 磁场对生物体有一定作用, 但是磁场对于人类或实验动物的学习记忆是否有影响, 目前的报道结果很不一致。
本实验采用实验小白鼠, 给予不同强度( 65 高斯/ 50Hz, 35 高斯/ 25Hz) 的低频磁场照射( 每天1 小时, 持续25 天) 。磁场照射后, 采
用旷场行为测试、Y- 迷宫和Morris 水迷宫, 检测小鼠的活动性、空间辨别、空间学习记忆和非空间学习记忆能力。结果表明: 65
高斯/ 50Hz 磁场显著增高小鼠的活动性, 并损伤小鼠Y- 迷宫的空间辨别能力, 但对Morris 水迷宫的空间、非空间学习记忆无明
显影响。35 高斯/ 25Hz 磁场处理动物行为在三个指标上均接近对照组。提示: 长期的磁场照射可能会给动物, 甚至人类造成一
些影响。 |
| 英文摘要: |
| Objective: The magnetic field affects the organisms in many aspects. However, previous studies showed that effects of
the magnetic field on learning and memory in animals are conflicting. In this study, we examined whether two pulsed magnetic fields ( 65G/ 50Hz,
35G/ 25Hz) influenced memory and locomotor activity in ICR mice. Methods: The mice were exposed to different pulsed magnetic fields 1 hour
per day for 25 days running, and then they were measured spatial discrimination memory, spatial and non- spatial memory and locomotor activity
by using Y- maze, Morris water maze and open- field tests respectively. Results: When exposed to 65G/ 50Hz magnetic field, the locomotor
activity increased and spatial discrimination memory impaired in Y- maze, however, showing no effect on performance in Morris water maze.
Compared with control group, mice treated with the 35G/ 25Hz magnetic field had similar performance. Conclusion: Long time low pulsed
magnetic field could influence the behavior in mice, even human behavior. |
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