| 谭大勇 简 丽 吴味辛.妊娠肝内胆汁淤积症胎儿猝死发病机制的研究进展[J].现代生物医学进展英文版,2006,6(2):91-92. |
| 妊娠肝内胆汁淤积症胎儿猝死发病机制的研究进展 |
| Study advance to fetal sudden death in the late trimester in intrahepatic cholestasis of pregnancy |
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| DOI： |
| 中文关键词: 妊娠肝内胆汁淤积症 胎儿 猝死 胆汁酸 |
| 英文关键词: intrahepatic cholestasis of pregnancy fetal sudden death bile acid |
| 基金项目: |
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| 中文摘要: |
| 妊娠肝内胆汁淤积症( ICP) 妊娠晚期胎儿猝死, 难以预料和准确监测, 具有高风险性。目前其机制不明。孕妇和胎儿
高胆汁酸水平对胎盘功能的影响和对胎儿的损伤是当前研究的主要方向。特别是一系列胆汁酸对心肌细胞毒性作用的实验, 提
示胆汁酸对胎儿心脏的毒性作用可能是引起胎儿猝死的重要原因。 |
| 英文摘要: |
| Fetal sudden death in the late trimester in intrahepatic cholestasis of pregnancy( ICP) is hard to anticipate and monitor, therefore
with high risk. It. s mechanism is still unkown. The mian research direction nowadays is the influence to the placenta and the damnification to
the fetal because of the high serum bile acid level in the pregnant woman and fetal. Especailly a series of resear ches on the bile acid impairing
cardiomyocyte function have proved the cytotox ity of bile acids to the fetal heart is the vital factor that leads the sudden death of fetal. |
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