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目的: 观察环磷酰苷葡胺注射液治疗充血性心力衰竭的疗效。方法: 将243 例充血性心力衰竭患者随机分为两组: 观察组121 例, 对照组122 例。对照组患者给予地高辛0. 125~ 0. 25mg 或西地兰0. 2mg 加入注射用水20ml, 每日1- 2 次静推, 利尿剂给予速尿20- 40mg, 隔日口服或静推, 同时补钾3 次/ 日, 疗程4- 8 周。观察组在应用上述药物的基础上, 给予5%葡萄糖200 - 500ml 加入环磷酰苷葡胺注射液60~ 80mg, 1 次/ 日静点, 或25%葡萄糖加入环磷酰苷胺注射液90mg 1 次/ 日静推, 疗程4- 8 周。结果: 两组心功能较治疗前明显改善。结论: 环磷酰苷胺治疗充血性心力衰竭疗效确切, 安全可靠, 值得临床推广应用。

英文摘要:

Objective: To study the effect of Adenosine Cyclophosphate( AC) in the treatment of congestive cardiac failure( CCF) . Methods: 243 patients( male: 131, female: 112) with CCF were randomly divided into two groups: observation group( n= 121) and control group( n= 122) . The control group was given digoxin 0. 125~ 0. 25mg or cedilanid o. 2mg with water for injection 20ml( IV, once or twice a day) , furosemide( FS) 20- 40mg( orally every other day or IV) , meanwhile, adding kalium( three times a day) for 4- 8 weeks; On the basis of the above- given medicines, the observation group was administered 5% glucose in water 200- 500ml with AC 60- 80mg ( once a day, IV drop) or D25%W with AC 90mg( once a day, IV) for 4- 8 weeks. Heart, hepatic and renal functions of the patients with CCF as well as medicinal side effects were observed. Results: After treatment, heart function of the patients in the two groups was improved better than that before treatment. Conclusion: Using AC to treat CCF can acquire better curative effects, therefore,which is worth spreading in clinical application.

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