| 张清媛 康欣梅 赵文辉.小剂量环磷酰胺联合参一胶囊治疗进展期非小细胞肺癌[J].现代生物医学进展英文版,2006,6(2):50-52. |
| 小剂量环磷酰胺联合参一胶囊治疗进展期非小细胞肺癌 |
| The efficacy analysis of low- dose cyclophosphamide combined withginsenoside Rg3 on advanced non- small cell lung cancer |
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| DOI： |
| 中文关键词: 小剂量环磷酰胺( CTX) 人参皂甙Rg3 抗血管生成 非小细胞肺癌 疗效 |
| 英文关键词: Low- dose cyclophosphamide( CTX) Ginsenoside Rg3 Antiangiogensis Advanced non- small cell lung cancer Efficacy |
| 基金项目: |
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| 中文摘要: |
| 目的: 应用小剂量环磷酰胺( CTX) 联合参一胶囊治疗III、IV 期非小细胞肺癌, 观察其临床疗效及毒副作用。方法: III、
IV 期非小细胞肺癌患者经标准化、放疗后随机分为两组, 治疗组( 38 例) : CTX 50mg 每日一次、参一胶囊20mg 每日两次口服, 三至
六个月; 对照组( 34 例) : 化疗后不用任何药物治疗。结果: 联合治疗组患者外周血血管内皮生长因子( VEGF) 表达下降, T 淋巴细
胞亚群CD4+ 及CD4+ / CD8+ 升高, 病人生存质量及生存期提高。结论: III、IV 期NSCLC 患者化疗后联合应用小剂量CTX 联合
参一胶囊治疗是一种安全有效的治疗方法, 可以提高患者的生存质量及生存期。 |
| 英文摘要: |
| Objective: To investigate its toxicity and efficacy of low- dose cyclophosphamide( CTX) and ginsenoside Rg3 in treating patients
with advanced non- small cell lung cancer. Methods: 72 patients with non- small cell lung cancer , who were diagnosed Stage ?? or ?? by
pathology and had been treated with chemotherapy and radiotherapy, were randomly divided into two groups: the therapeutic group( n= 38) was
given CTX 50mg qd po plus ginsenoside Rg3 20mg bid po for three to six months; the control group wasn?? t given any medication after chemotherapy.
The clinical data of all the patients in the two groups were analysed when and after medication. Results: The results showed that in the therapeutic
group, TTP( = tumor time of progression) was 7 months and meso life span was 19. 5 months and annual survival rate was 63. 2%; while
in the control group, TTP 4 months and meso life span 13. 5% and annual survival rate 52. 9%. The serum VEGF( = vascular endothelial growth
factor) in the therapeutic group was lower than that in the control group after medication. CD4+ , CD4+ / CD8+ after treatment in the therapeutic
group were higher than those before treatment. Conclusion: This experiment is proved to be a new safe anticancer therapy, which can improve life
quality of the patients and prolong their life span. |
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