| Objective: To explore the impact of marital status on the prognosis of adult patients with primary intrahepatic cholangiocarcinoma. Method: 3283 patients with primary intrahepatic single tube carcinoma from 1998 to 2018 were collected. They were divided into married group (n=1999) and unmarried group (n=1284) based on marital status. The clinical data of adult patients with primary intrahepatic cholangiocarcinoma of different marital statuses were compared. Kaplan Meier survival curves were used to analyze the survival status of adult patients with primary intrahepatic cholangiocarcinoma in different marital statuses. Univariate and multivariate Cox regression analysis were used to investigate the factors affecting the survival of adult patients with primary intrahepatic cholangiocarcinoma. Kaplan Meier survival curves were used to analyze the survival status of adult patients with primary intrahepatic cholangiocarcinoma in different marital statuses, including whether they received surgical treatment, radiotherapy treatment, and gender differences. Result: The proportion of male patients, the proportion of white patients, the proportion of patients over 60 years old, the proportion of patients receiving surgical treatment, the proportion of patients receiving radiotherapy, and the proportion of patients receiving chemotherapy in the married group were higher than those in the unmarried group (P<0.05). Kaplan Meier survival curve analysis results showed that, the 3-month and 5-year survival rates between married and unmarried groups were Log rank test P<0.05. Multivariate Cox regression analysis showed that, age over 60 years old, later tumor stage, surgical treatment, radiotherapy, and chemotherapy were risk factors for survival in adult patients with primary intrahepatic cholangiocarcinoma (P<0.05). Kalplan Meier survival curve results showed that, there was no significant difference in 5-year survival rate between married and unmarried adult patients with primary intrahepatic cholangiocarcinoma who received surgical treatment (Log Rank test P=0.381). There was a significant difference in the 5-year survival rate between married and unmarried adult patients with primary intrahepatic cholangiocarcinoma who have not received surgical treatment (Log Rank test P=0.015). There was no significant difference in 5-year survival rate between married and unmarried adult patients with primary intrahepatic cholangiocarcinoma who received radiotherapy (Log Rank test P=0.073). There was a significant difference in the 5-year survival rate between married and unmarried adult patients with primary intrahepatic cholangiocarcinoma who have not received radiotherapy (Log Rank test P<0.001). There was no significant difference in 5-year survival rate between married and unmarried adult patients with primary intrahepatic cholangiocarcinoma who received chemotherapy (Log Rank test P=0.337). There was a significant difference in the 5-year survival rate between married and unmarried adult patients with primary intrahepatic cholangiocarcinoma who have not received chemotherapy (Log Rank test P<0.001). There was no significant difference in the survival status of male patients with primary intrahepatic cholangiocarcinoma in adults of different marital statuses (Log Rank test P=0.136). There were differences in the survival status of female patients with primary intrahepatic cholangiocarcinoma in adults of different marital statuses (Log Rank test P<0.001). Conclusion: Male, white, and over 60 years old are risk factors for the occurrence of primary intrahepatic cholangiocarcinoma in adults. Among them, more than half of the patients did not receive surgery or radiotherapy treatment, and about half of the patients did not receive chemotherapy. Married individuals are more likely than unmarried individuals to undergo anti-tumor treatments such as surgery, radiotherapy and chemotherapy. The staging of intrahepatic cholangiocarcinoma and whether surgery or chemotherapy is received are independent predictors of long-term survival. Marital status is not an independent predictor and can indirectly affect long-term survival. Male marital status has no significant survival benefits for this disease, while female marital status has survival benefits for this disease. The marital status of patients with intrahepatic cholangiocarcinoma who have not undergone radiotherapy, chemotherapy, or surgical intervention has a significant impact on their survival outcomes. |
