| 蔡 渝,谢艳君,官 彬,陈德全,游兴攀,彭 虹.钆贝葡胺增强磁共振成像对肝硬化患者肝功能和肝纤维化的评估价值[J].,2025,(1):154-160 |
| 钆贝葡胺增强磁共振成像对肝硬化患者肝功能和肝纤维化的评估价值 |
| Evaluation Value of Gadobenate Dimeglumine Enhanced Magnetic Resonance Imaging for Liver Function and Liver Fibrosis in Cirrhosis Patients |
| 投稿时间：2024-10-11 |
| DOI：10.13241/j.cnki.pmb.2025.01.022 |
| 中文关键词: 肝硬化 钆贝葡胺 增强磁共振成像 肝功能 肝纤维化 |
| 英文关键词: Cirrhosis Gadobenate dimeglumine Enhanced magnetic resonance imaging Liver function Liver fibrosis |
| 基金项目:重庆市合川区科技计划项目（hckj-[2020]17-23） |
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| 中文摘要: |
| 摘要 目的：分析钆贝葡胺（Gd-BOPTA）增强磁共振成像（MRI）评估肝硬化患者肝功能、肝纤维化的临床价值。方法：选择2021年3月至2023年2月于本院就诊的100例肝硬化患者，按照Child-Pugh分级将患者分为A级组（54例）、B级组（32例）、C级组（14例），另选90例健康体检者作为正常组，所有受检者均接受腹部Gd-BOPTA增强MRI检查并获取肝实质相对强化程度（RE），对比4组肝实质RE、肝功能指标、肝纤维化指标，经Pearson相关性分析肝实质RE与肝功能、肝纤维化指标的关系。结果：A级、B级和C级组患者肝实质RE低于正常组，且A级、B级和C级组患者肝实质RE值逐渐降低（P＜0.05）；A级、B级和C级组患者天门冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）、总胆红素（TBIL）水平高于正常组，且A级、B级和C级组患者AST、ALT、TBIL水平逐渐升高（P＜0.05）；A级、B级和C级组患者IV型胶原（IV-C）、Ⅲ型前胶原（PCⅢ）、层粘蛋白（LN）、透明质酸（HA）水平高于正常组，且A级、B级和C级组患者IV-C、PCⅢ、LN、HA水平逐渐升高（P＜0.05）；Pearson相关性分析发现，肝实质RE与AST、ALT、TBIL、IV-C、PCⅢ、LN、HA呈负相关（P＜0.001）。结论：Gd-BOPTA增强MRI检查获取的肝实质RE值与肝硬化患者肝功能、肝纤维化呈负相关，Gd-BOPTA增强MRI有助于评估肝硬化患者肝功能和肝纤维化。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the clinical value of gadobenate dimeglumine (Gd-BOPTA) enhanced magnetic resonance imaging (MRI) in evaluating liver function and liver fibrosis in cirrhosis patients. Methods: 100 cirrhosis patients who were admitted in our hospital from March 2021 to February 2023 were selected, patients were divided into grade A group (54 cases), grade B group (32 cases) and grade C group (14 cases) according to Child-Pugh classification, and 90 healthy subjects were selected as the normal group, all subjects underwent abdominal Gd-BOPTA-enhanced MRI and the liver parenchyma enhancement (RE) was obtained, the liver parenchyma RE, liver function index and liver fibrosis index of the four groups were compared, and the relationship between liver parenchyma RE and liver function and liver fibrosis index was analyzed by Pearson correlation. Results: The liver parenchyma RE in patients with grade A, grade B and grade C was lower than that in normal group, and the RE value of liver parenchyma in patients with grade A, grade B and grade C gradually decreased (P<0.05). The aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total bilirubin (TBIL) levels in grade A, grade B and grade C groups were higher than those in normal group, and the AST, ALT, TBIL levels in grade A, grade B and grade C groups were gradually increased (P<0.05). The type IV collagen (IV-C), type III procollagen (PCIII), laminin (LN) and hyaluronic acid (HA) levels in grade A, grade B and grade C groups were higher than those in normal group, and IV-C, PCIII, LN, HA levels in grade A, grade B and grade C groups gradually increased (P<0.05). Pearson correlation analysis found that liver parenchyma RE was negatively correlated with AST, ALT, TBIL, IV-C, PCIII, LN and HA (P<0.001). Conclusion: The liver parenchyma RE obtained by Gd-BOPTA enhanced MRI is negatively correlated with liver function and liver fibrosis in cirrhosis patients, Gd-BOPTA enhanced MRI is helpful to evaluate liver function and liver fibrosis in cirrhosis patients. |
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