| 杜雪梅,吕 宏,周文婷,邹晓红,何晓凤.CD3+、CD8+调节性T细胞与结肠癌术后复发的关系及列线图预测模型构建[J].,2025,(1):132-138 |
| CD3+、CD8+调节性T细胞与结肠癌术后复发的关系及列线图预测模型构建 |
| Relationship between CD3+, CD8+ Regulatory T Cells with the Recurrence of Colon Cancer after Surgery, and the Construction of the Nomogram Prediction Model |
| 投稿时间：2024-10-15 |
| DOI：10.13241/j.cnki.pmb.2025.01.019 |
| 中文关键词: 调节性T细胞 结肠癌 复发 列线图预测模型 |
| 英文关键词: Regulatory T cells Colon cancer Relapse Nomogram prediction model |
| 基金项目:四川省卫健委医学科研项目（18PJ429）； 四川省成都市龙泉驿区卫健系统科研课题（WJKY006） |
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| 中文摘要: |
| 摘要 目的：探究CD3+、CD8+调节性T细胞与结肠癌患者术后复发的相关性并构建列线图模型，分析其预测价值。方法：选取2018年12月至2020年11月我院收治的170例结肠癌患者，根据术后3年的复发情况，分为复发组（n=22）和未复发组（n=148）。对比两组患者术前CD3+、CD8+占比，采用多因素Logistic回归分析影响因素，构建列线图预测模型并采用受试者工作特征（ROC）曲线评价预测效能。结果：复发组患者CD3+占比低于未复发组患者，CD8+占比高于未复发组（P<0.05）。TNM分期、肿瘤病灶位置、淋巴结转移、术前癌胚抗原（CEA）、CD8+是结肠癌患者复发的独立危险因素，CD3+是其保护因素（P<0.05）。列线图模型预测结肠癌患者术后复发风险的曲线下面积（AUC）为0.892（95% CI: 0.808~0.975）。结论：结肠癌术后复发患者CD3+、CD8+调节性T细胞水平异常，TNM分期、肿瘤病灶位置、淋巴结转移、术前CEA、CD8+、CD3+是结肠癌患者复发的影响因素。根据影响因素构建的列线图预测模型对结肠癌患者术后复发情况具有较高的预测价值，有助于临床医生更好地评估患者术后复发风险，制定个性化的治疗方案。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the correlation between CD3+ and CD8+ regulatory T cells with postoperative recurrence in colon cancer patients and construct the nomogram model to analyze predictive value. Methods: A total of 170 patients with colon cancer in our hospital from December 2018 to November 2020 were selected, and divided into recurrence group (n=22) and no recurrence group (n=148) according to the recurrence situation in 3 years after surgery. Multivariate Logistic regression was used to analyze the influencing factors, a nomogram prediction model was constructed and receiver operating characteristic (ROC) curve was used to evaluate the prediction efficiency. Results: The proportion of CD3+ in the relapse group was lower than that in the no relapse group, and the proportion of CD8+ was higher than that in no relapse group(P<0.05). TNM staging, tumor focus location, lymph node metastasis, preoperative carcinoembryonic antigen (CEA) and CD8+ were independent risk factors for recurrence of colon cancer, and CD3+ was protective factor (P<0.05). The area under the curve (AUC) predicted by the nomogram model for postoperative recurrence risk of colon cancer patients was 0.892 (95% CI: 0.808~0.975). Conclusion: CD3+, CD8+ regulatory T cells level in patients with recurrent colon cancer after surgery is abnormal. TNM staging, tumor focus location, lymph node metastasis, preoperative CEA, CD8+, and CD3+ were the influencing factors for recurrence in patients with colon cancer. The nomogram prediction model constructed according to the influencing factors has high predictive value for the prognostic recurrence of colon cancer patients, and helps clinicians to better evaluate the risk of postoperative recurrence and develop personalized treatment plan. |
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