| 杨佳白,刘颖璇,张 宇,李胜男,蔡玉洁,崔理立.急性缺血性脑卒中患者血浆CXCL9、CCL21与病情和预后的关系研究[J].,2025,(1):99-105 |
| 急性缺血性脑卒中患者血浆CXCL9、CCL21与病情和预后的关系研究 |
| Study of the Relationship between Plasma CXCL9, CCL21 and the Condition and Prognosis of Patients with Acute Ischemic Stroke |
| 投稿时间：2024-07-17 |
| DOI：10.13241/j.cnki.pmb.2025.01.014 |
| 中文关键词: 急性缺血性脑卒中 C-X-C基序趋化因子配体9 C-C基序趋化因子配体21 病情 预后 |
| 英文关键词: Acute ischemic stroke C-X-C motif chemokine ligand 9 C-C motif chemokine ligand 21 Condition Prognosis |
| 基金项目:国家自然科学基金项目（82071190）；广东省医学科研基金资助项目（A2022139） |
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| 中文摘要: |
| 摘要 目的：探讨急性缺血性脑卒中（AIS）患者血浆C-X-C基序趋化因子配体9（CXCL9）、C-C基序趋化因子配体21（CCL21）与病情和预后的关系。方法：选取2020年1月～2023年9月北京市和平里医院收治的AIS患者197例（AIS组）和同期100例健康体检者（对照组），AIS患者根据病情分为轻度AIS组（39例）、中度AIS组（54例）、中重度AIS组（31例）、重度AIS组（73例），根据出院后3个月的预后分为不良预后组（55例）和良好预后组（142例）。分析AIS患者血浆CXCL9、CCL21水平与病情以及预后的关系。结果：重度AIS组血浆CXCL9、CCL21水平高于中重度AIS组、中度AIS组、轻度AIS组和对照组（P均＜0.05）。AIS患者不良预后的独立危险因素为梗死体积增加、NIHSS评分增加和CXCL9、CCL21升高（P均＜0.05）。血浆CXCL9联合CCL21预测AIS患者预后不良的曲线下面积（AUC）最高，AUC为0.861。结论：AIS患者血浆CXCL9、CCL21水平升高，与病情加重和不良预后有关，血浆CXCL9联合CCL21预测AIS患者预后的效能良好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between plasma C-X-C motif chemokine ligand 9 (CXCL9), C-C motif chemokine ligand 21 (CCL21) and disease condition and prognosis in patients with acute ischemic stroke (AIS). Methods: 197 AIS patients (AIS group) and 100 healthy subjects (control group) admitted to Beijing Hepingli Hospital from January 2020 to September 2023 were selected, AIS patients were divided into mild AIS group (39 cases), moderate AIS group (54 cases), moderate-severe AIS group (31 cases) and severe AIS group (73 cases) according to their condition, patients were divided into poor prognosis group (55 cases) and good prognosis group (142 cases) according to the prognosis at 3 months after discharge. The relationship between plasma CXCL9, CCL21 levels and the condition and prognosis of AIS patients were analyzed. Results: The levels of plasma CXCL9 and CCL21 in severe AIS group were higher than those in moderate-severe AIS group, moderate AIS group, mild AIS group and control group (all P<0.05). The independent risk factors for poor prognosis in AIS patients were increased infarct volume, increased NIHSS score, and increased CXCL9 and CCL21 (all P<0.05). The area under the curve (AUC) of plasma CXCL9 combined with CCL21 in predicting poor prognosis of AIS patients was the highest, and the AUC was 0.861. Conclusion: The levels of plasma CXCL9 and CCL21 in AIS patients are increased, which are related to the aggravation of the disease and poor prognosis, and plasma CXCL 9 combined with CCL 21 predicted good prognosis in AIS patients. |
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