| 陈 征,李启亮,金 芳,张清秀,李爱华,梁雅慧.NT-proBNP、SAA、CRP与川崎病患儿病情严重程度及心血管病变易感性相关性的多项分类Logistic模型分析[J].,2025,(1):65-71 |
| NT-proBNP、SAA、CRP与川崎病患儿病情严重程度及心血管病变易感性相关性的多项分类Logistic模型分析 |
| Multivariate Logistic Model Analysis of the Correlation between NT-proBNP, SAA and CRP and the Severity of Kawasaki Disease and Cardiovascular Disease Susceptibility in Children |
| 投稿时间：2023-03-20 |
| DOI：10.13241/j.cnki.pmb.2025.01.009 |
| 中文关键词: N末端B型利钠肽 淀粉样蛋白 A C反应蛋白 川崎病 |
| 英文关键词: N-terminal B-type natriuretic peptide Amyloid protein a C-reactive protein Kawasaki disease |
| 基金项目:中国康复医疗机构联盟基金资助项目（20160304） |
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| 中文摘要: |
| 摘要 目的：采用多项分类Logistic模型分析N末端B型利钠肽（NT-proBNP）、淀粉样蛋白 A（SAA）、C反应蛋白（CRP）与川崎病患儿病情严重程度及心血管病变易感性的相关性。方法：选取2020.02~2022.08在我院治疗的川崎病患儿，共纳入例数为120例，将其作为研究组。另选取在同一时间段内我院接收的健康体检儿童作为对照组，对照组例数为60例。根据患儿是否发生心血管病变分为心血管病变组和无心血管病变组，分别有64例、56例。根据患儿超声心电图检查结果，判断患儿疾病的严重程度，将患儿分为冠状动脉损害组和无冠状动脉损害组，分别有38例、82例。采用散射免疫比浊法测定患儿血清中SAA、CRP水平，采用全自动化学发光免疫分析仪测定患儿血清中NT-proBNP水平。结果：研究组患儿血清NT-proBNP、SAA、CRP水平均显著高于对照组（P<0.05）。冠状动脉损害组患儿治疗前发热时间显著长于无冠状动脉损害组（P<0.05）；冠状动脉损害组患儿血清NT-proBNP、SAA、CRP水平均显著高于无冠状动脉损害组（P<0.05）。心血管病变组患儿血清NT-proBNP、SAA、CRP水平均显著高于无心血管病变组（P<0.05）。患儿年龄与川崎病严重程度呈明显的负相关（P<0.05），治疗前发热时间、血清NT-proBNP、SAA、CRP水平均与川崎病严重程度及心血管病变易感性呈明显的正相关（P<0.05）。Logistic结果显示，川崎病患儿病情加重及心血管病变易感性的危险因素均包括血清NT-proBNP、SAA、CRP，而川崎病患儿病情加重的保护因素为年龄（P<0.05）。结论：NT-proBNP、SAA、CRP均是川崎病患儿病情加重及心血管病变易感性的危险因素。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the correlation between N-terminal B-type natriuretic peptide (NT-proBNP), amyloid A(SAA) and C-reactive protein (CRP) and the severity of Kawasaki disease and the susceptibility of cardiovascular disease in children with multiple classification Logistic model. Methods: Children with Kawasaki disease treated in our hospital from February 2020 to August 2022 were selected, and 120 cases were included as the research group. In addition, the healthy children admitted to our hospital in the same time period were selected as the control group, and the number of cases in the control group was 60. According to whether the children have cardiovascular disease or not, they were divided into cardiovascular disease group and cardiovascular disease group, with 64 cases and 56 cases respectively. According to the results of ultrasonic electrocardiogram examination, the severity of the disease was judged, and the children were divided into coronary artery damage group and non-coronary artery damage group, with 38 cases and 82 cases respectively. The levels of SAA and CRP in children's serum were determined by scattering immunoturbidimetry, and the level of NT-proBNP in children's serum was determined by automatic chemiluminescence immunoassay. Results: The serum levels of NT-proBNP, SAA and CRP in the study group were significantly higher than those in the control group (P<0.05). The fever time of children with coronary artery injury before treatment was significantly longer than that of children without coronary artery injury (P<0.05). The serum levels of NT-proBNP, SAA and CRP in children with coronary artery injury were significantly higher than those in children without coronary artery injury (P<0.05). The levels of serum NT-proBNP, SAA and CRP in children with coronary heart disease were significantly higher than those in children without coronary heart disease (P<0.05). The age of the children was negatively correlated with the severity of Kawasaki disease (P<0.05), and the fever time before treatment, serum NT-proBNP, SAA and CRP levels were positively correlated with the severity of Kawasaki disease and the susceptibility to cardiovascular disease (P<0.05). Logistic results showed that the risk factors of Kawasaki disease children's aggravation and cardiovascular disease susceptibility included serum NT-proBNP, SAA and CRP, while the protective factor of Kawasaki disease children's aggravation was age (P<0.05). Conclusion: NT-proBNP, SAA and CRP are all risk factors for the aggravation of Kawasaki disease and the susceptibility to cardiovascular disease. |
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