| 杜 丽,杨见辉,崔玉霞,陈 娜,王 乔.基于NLRP3炎症小体和Th1/Th2平衡探讨加味五虎汤联合小儿推拿治疗肺炎支原体肺炎患儿的疗效及其作用机制[J].,2025,(1):46-52 |
| 基于NLRP3炎症小体和Th1/Th2平衡探讨加味五虎汤联合小儿推拿治疗肺炎支原体肺炎患儿的疗效及其作用机制 |
| Explore the Clinical Efficacy of Jiawei Wuhu Decoction Combined with Pediatric Massage in the Treatment of Mycoplasma Pneumoniae Pneumonia Children Based on NLRP3 Inflammasome and Th1/Th2 Balance |
| 投稿时间：2024-09-09 |
| DOI：10.13241/j.cnki.pmb.2025.01.006 |
| 中文关键词: NOD样受体蛋白3炎症小体 辅助性T细胞1/辅助性T细胞2平衡 加味五虎汤 小儿推拿 肺炎支原体肺炎 临床疗效 |
| 英文关键词: NLRP3 inflammasome Th1/Th2 balance Jiawei wuhu decoction Pediatric massage Mycoplasma pneumoniae pneumonia Clinical efficacy |
| 基金项目:国家自然科学基金项目（81860003） |
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| 中文摘要: |
| 摘要 目的：基于NOD样受体蛋白3（NLRP3）炎症小体和辅助性T细胞（Th）1/Th2平衡探讨加味五虎汤联合小儿推拿治疗肺炎支原体肺炎（MPP）患儿的疗效及其作用机制。方法：将2022年10月-2023年10月期间贵州中医药大学第二附属医院收治的141例痰热闭肺型MPP患儿按照随机数字表法分为对照组（70例，西药联合小儿推拿治疗）、观察组（71例，对照组基础上联合加味五虎汤治疗）。对比两组治疗前、治疗7 d后的中医证候积分、肺功能指标[用力肺活量（FVC）、第1秒最大呼气量（FEV1）、峰值呼气流速（PEF）]、NLRP3信使核糖核酸（mRNA）、半胱氨酸天冬氨酸蛋白水解酶-1（caspase-1） mRNA表达水平和下游因子白细胞介素（IL）-1β、IL-18、Th1/Th2相关因子[肿瘤坏死因子-α（TNF-α）、IL-6、IL-4、γ-干扰素（IFN-γ）]。结果：治疗7 d后，两组主症、次症、总分、NLRP3 mRNA、caspase-1 mRNA、IL-1β、IL-18、IL-4、IL-6、TNF-α、IFN-γ下降，且观察组低于对照组同时间点（P<0.05）。治疗7 d后，两组FVC、FEV1、PEF升高，且观察组高于对照组同时间点（P<0.05）。结论：加味五虎汤联合小儿推拿治疗MPP患儿，可通过调节NLRP3炎症小体和改善Th1/Th2平衡，促进患儿临床症状好转和肺功能恢复。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical efficacy of jiawei wuhu decoction combined with pediatric massage in the treatment of mycoplasma pneumoniae pneumonia (MPP) children based on NOD-like receptor protein 3 (NLRP3) inflammasome and helper T cell (Th) 1/Th2 balance. Methods: From October 2022 to October 2023, 141 children with phlegm-heat MPP treated in the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine were divided into control group (70 cases, western medicine combined with pediatric massage therapy) and observation group (71 cases, combined with flavored Wuhu soup treatment on of control group) according to random number table method. The traditional chinese medicine syndrome scores, lung function indexes [forced vital capacity (FVC), maximum expiratory volume in the first second (FEV1), peak expiratory flow rate (PEF)], NLRP3 messenger ribonucleic acid (mRNA), cysteine aspartic acid proteolytic enzyme-1 (caspase-1) mRNA expression levels and downstream factors interleukin-1β (IL)-1β, IL-18, Th1/Th2 related factors [tumor necrosis factor-α (TNF-α), IL-6, IL-4, γ-interferon (IFN-γ)] were compared between two groups before treatment and 7 days after treatment. Results: 7 days after treatment, the main symptoms, secondary symptoms, total scores, NLRP3 mRNA, caspase-1 mRNA, IL-1β, IL-18, IL-4, IL-6, TNF-α and IFN-γ in two groups decreased, and observation group were lower 7 days after treatment (P<0.05). 7 days after treatment, FVC, FEV1 and PEF in two groups increased, and observation group were higher than those of control group at the same time point (P<0.05). Conclusion: Jiawei wuhu decoction combined with pediatric massage in the treatment of MPP children, which can promote the improvement of clinical symptoms and the recovery of lung function by regulating NLRP3 inflammasome and improving Th1/Th2 balance. |
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