| 张晓军,徐巧玲,赵于天,沈培佩,徐 钰,李 帅.晚期非小细胞肺癌患者三维适形放疗前后血清SPP1、E-cadherin、
STAT3变化及临床意义[J].,2024,(23):4578-4580 |
| 晚期非小细胞肺癌患者三维适形放疗前后血清SPP1、E-cadherin、
STAT3变化及临床意义 |
| Changes and Clinical Significance of Serum SPP1, E-cadherin and STAT3in Patients with Advanced Non-Small Cell Lung Cancerbefore and after Three-Dimensional Conformal Radiotherapy |
| 投稿时间：2024-08-09 修订日期：2024-09-01 |
| DOI：10.13241/j.cnki.pmb.2024.23.050 |
| 中文关键词: 晚期非小细胞肺癌 三维适形放疗 分泌磷酸蛋白1 E-钙黏蛋白 信号传导与转录激活因子3 |
| 英文关键词: Advanced non-small cell lung cancer Three-dimensional conformal radiotherapy Secreted phosphoprotein 1 E-cadherin Signal transducer and activator of transcription 3 |
| 基金项目:无锡市卫生健康委转化医学研究专项（ZH202103）；江苏省自然科学基金项目（BK20151108） |
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| 中文摘要: |
| 摘要 目的：探讨晚期非小细胞肺癌（NSCLC）患者三维适形放疗前后血清分泌磷酸蛋白1（SPP1）、E-钙黏蛋白（E-cadherin）、信号传导与转录激活因子3（STAT3）水平变化及临床意义。方法：选择146例晚期NSCLC患者作为NSCLC组，同期我院体检的75例健康者为对照组。根据疗效分为有效组、无效组。晚期NSCLC患者随访12个月，根据生存情况分为生存组、死亡组。结果：NSCLC组放疗前血清SPP1、STAT3水平高于对照组，血清E-cadherin水平低于对照组（P＜0.05）。放疗结束后146例晚期NSCLC患者总有效率为47.95%（70/146）。无效组放疗前、放疗后血清SPP1、STAT3水平均高于有效组，血清E-cadherin水平均低于有效组（P＜0.05）。死亡组放疗前血清SPP1、STAT3水平高于生存组，血清E-cadherin水平低于生存组（P＜0.05）。结论：晚期NSCLC患者放疗前血清SPP1、STAT3水平高表达，血清E-cadherin水平低表达，接受三维适形放疗后血清SPP1、STAT3水平降低，血清E-cadherin水平升高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the changes and clinical significance of serum secreted phosphoprotein 1 (SPP1), E-cadherin and signal transducer and activator of transcription 3 (STAT3) levels in patients with advanced non-small cell lung cancer (NSCLC) before and after three-dimensional conformal radiotherapy. Methods: 146 patients with advanced NSCLC were selected as NSCLC group, and 75 healthy people who underwent physical examination in our hospital during the same period were selected as control group. Patients were divided into effective group and ineffective group according to the efficacy. Patients with advanced NSCLC were followed up for 12 months, they were divided into survival group and death group according to the survival status. Results: The levels of serum SPP1 and STAT3 in NSCLC group before radiotherapy were higher than those in control group, and the level of serum E-cadherin was lower than that in control group (P<0.05). The total effective rate of 146 patients with advanced NSCLC after radiotherapy was 47.95% (70/146). The serum SPP1 and STAT3 levels in ineffective group were higher than those in effective group before and after radiotherapy, and the serum E-cadherin level was lower than that in effective group (P<0.05). The serum SPP1 and STAT3 levels in death group before radiotherapy were higher than those in survival group, and the serum E-cadherin level was lower than that in survival group (P<0.05). Conclusion: The levels of serum SPP1 and STAT3 in patients with advanced NSCLC were highly expressed before radiotherapy, and the level of serum E-cadherin was low, the levels of serum SPP1 and STAT3 decreased after three-dimensional conformal radiotherapy, and the level of serum E-cadherin increased. |
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