| 汤翠翠,陈京霞,彭亮红,李征亚,陈 刚,吴任萍.增生型糖尿病性视网膜病变患者房水TNC、Sema3A、MCP-1
与术后新生血管性青光眼的关系分析[J].,2024,(23):4574-4577 |
| 增生型糖尿病性视网膜病变患者房水TNC、Sema3A、MCP-1
与术后新生血管性青光眼的关系分析 |
| Analysis of the Relationship between Aqueous Humor TNC, Sema3A, MCP-1 and Postoperative Neovascular Glaucoma in Patients with Proliferative Diabetic Retinopathy |
| 投稿时间：2024-05-16 修订日期：2024-06-12 |
| DOI：10.13241/j.cnki.pmb.2024.23.049 |
| 中文关键词: 增生型糖尿病性视网膜病变 腱生蛋白C 信号素3A 单核细胞趋化蛋白-1 新生血管性青光眼 |
| 英文关键词: Proliferative diabetic retinopathy Tenascin C Semaphorins 3A Monocyte chemoattractant protein-1 Neovascular glaucoma |
| 基金项目:广东省医学科学技术研究基金项目（20221118203122660）；广州市科技计划（2024A03J0694） |
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| 中文摘要: |
| 摘要 目的：分析增生型糖尿病性视网膜病变（PDR）患者房水腱生蛋白C（TNC）、信号素3A（Sema3A）、单核细胞趋化蛋白-1（MCP-1）与术后新生血管性青光眼（NVG）的关系。方法：：选取240例（300眼）PDR患者，均行玻璃体切割术治疗。患者术后随访1年，根据是否发生NVG将其分为并发NVG组与非并发NVG组。检测房水TNC、Sema3A、MCP-1水平，采用多因素logistic回归分析PDR患者术后NVG的影响因素。结果：240例（300眼）PDR患者术后1年发生NVG共55例（79眼），占比26.33%。并发NVG组房水TNC、Sema3A、MCP-1水平高于非并发NVG组（P＜0.05）。视网膜无灌注区残留，同侧颈动脉狭窄>25%，TNC、Sema3A、MCP-1水平升高是PDR患者术后NVG发生的独立危险因素（P＜0.05）。结论：房水TNC、Sema3A、MCP-1高表达为PDR患者术后NVG发生的独立危险因素。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the relationship between aqueous humor tenascin C (TNC), semaphorins 3A (Sema3A), monocyte chemoattractant protein-1 (MCP-1) and postoperative neovascular glaucoma (NVG) in patients with proliferative diabetic retinopathy (PDR). Methods: 240 (300 eyes) patients with PDR were selected, all patients underwent vitrectomy. Patients were followed up for 1 year after operation, and they were divided into concurrent NVG group and non-concurrent NVG group according to whether NVG occurred or not. The levels of TNC, Sema3A and MCP-1 in aqueous humor were detected, the influencing factors of postoperative NVG in PDR patients were analyzed by multivariate logistic regression. Results: 240 (300 eyes) of PDR patients had NVG in 55 cases (79 eyes) at 1 year after operation, accounting for 26.33%. The levels of aqueous humor TNC, Sema3A and MCP-1 in concurrent NVG group were higher than those in non-concurrent NVG group (P<0.05). Residual retinal perfusion zone, ipsilateral carotid artery stenosis>25%, and elevated TNC, Sema3A, and MCP-1 levels were independent risk factors for postoperative NVG in patients with PDR (P<0.05). Conclusion: The high expression of TNC, Sema3A and MCP-1 in aqueous humor are independent risk factor for postoperative NVG in PDR patients. |
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