| 张 琰,巩 楠,李羿兴,佐力克,谷申森.miR-592、miR155-5P及 miR20a对肺癌远处转移的判定
及预后预测价值[J].,2024,(23):4559-4561 |
| miR-592、miR155-5P及 miR20a对肺癌远处转移的判定
及预后预测价值 |
| The Diagnostic and Prognostic Value of miR-592, miR155-5P,and miR20a in Distant Metastasis of Lung Cancer |
| 投稿时间：2024-05-16 修订日期：2024-06-12 |
| DOI：10.13241/j.cnki.pmb.2024.23.044 |
| 中文关键词: 微小RNA 肺癌 远处转移 预后预测 |
| 英文关键词: MicroRNAs Lung cancer Distant metastasis Prognostic prediction |
| 基金项目:新疆维吾尔自治区自然科学基金项目（2021D01C304） |
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| 摘要点击次数: 19 |
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| 中文摘要: |
| 摘要 目的：探讨miR-592、miR155-5P及 miR20a对肺癌远处转移的判定及预后预测价值。方法：选取2019.1-2022.1收治的100例肺癌患者，分为远处转移组、非远处转移组。检测各组miR-592、miR155-5P及 miR20a表达水平并分析诊断价值。1年随访后分为预后不良组、预后良好组，对比资料，并分析预测价值。结果：远处转移组癌组织miR-592、miR155-5P及 miR20a相对表达量高于非远处转移组（P＜0.05）；miR-592、miR155-5P及 miR20a三者联合对肺癌远处转移的诊断灵敏度、特异度高于三者单一诊断；预后良好组与预后不良组患者临床分期、远处转移、分化程度、miR-592、miR155-5P及 miR20a相对表达量对比差异显著（P＜0.05）；临床分期、远处转移、分化程度、miR-592、miR155-5P及 miR20a对肺癌预后不良具有独立预测价值（P<0.05）。结论：miR-592、miR155-5P及 miR20a三者结合对于肺癌远处转移的诊断灵敏度、特异度较高，且可对肺癌预后情况进行早期预测。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the determination and prognostic prediction value of miR-592, miR155-5P and miR20a for distant metastasis of lung cancer. Methods: A total of 100 lung cancer patients admitted to 2019.1-2022.1 were selected and divided into distant and non-distant metastasis groups. The expression levels of miR-592, miR155-5P and miR20a in each group were tested and analyzed for diagnostic value. After 1-year follow-up, it was divided into poor prognosis and good prognosis, data were compared and predictive value was analyzed. Results: The relative expression level of miR-592, miR155-5P and miR20a in the distant metastasis group was higher than that in the non-distant metastasis group (P<0.05); The diagnostic sensitivity and specificity of miR-592, miR155-5P and miR20a for distant metastasis are higher than the single diagnosis of the three; The clinical stage, distant metastasis, differentiation, miR-592, miR155-5P and miR20a between the good prognosis and poor prognosis (P<0.05); Clinical stage, distant metastasis, degree of differentiation, miR-592, miR155-5P and miR20a had independent predictive value for poor prognosis of lung cancer (P<0.05). Conclusion: The combination of miR-592, miR155-5P and miR20a has high sensitivity and specificity for the diagnosis of distant metastasis of lung cancer patients, and can early predict the prognosis of lung cancer. |
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