| 田自开,张红玲,田晓星,吴 兵,庞晓东.骨肉瘤组织中同源盒蛋白2的表达及其与患者临床特征
及预后的关系研究[J].,2024,(23):4555-4558 |
| 骨肉瘤组织中同源盒蛋白2的表达及其与患者临床特征
及预后的关系研究 |
| Expression of Sine Oculis Homeobox Homolog 2 in Osteosarcomaand its Relationship with Clinical Characteristics and Prognosis |
| 投稿时间：2024-05-10 修订日期：2024-06-09 |
| DOI：10.13241/j.cnki.pmb.2024.23.043 |
| 中文关键词: 骨肉瘤 同源盒蛋白2 临床特征 预后 |
| 英文关键词: Osteosarcoma Sine oculis homeobox homolog 2 Clinical characteristics Prognosis |
| 基金项目:2022年度北京市自然科学基金面上项目（7222178） |
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| 中文摘要: |
| 摘要 目的：探讨骨肉瘤组织中同源盒蛋白2（Six2）的表达及其与患者临床特征及预后的关系。方法：54例原发性骨肉瘤患者作为本研究的对象。采用反转录-聚合酶链反应（RT-PCR）及免疫组化探索Six2在骨肉瘤组织中的表达。收集患者的临床信息，分析Six2与骨肉瘤患者临床特征之间的关系。对患者进行3年的随访，记录患者的生存资料信息，绘制生存分析曲线，探索Six2的表达与骨肉瘤预后的关系。结果：相对于癌旁正常组织，骨肉瘤组织Six2基因及蛋白水平呈高表达。Six2的表达与患者的是否远处转移相关（P<0.05）。Six2的表达水平越高，骨肉瘤患者的预后越差（P<0.05）。结论：Six2在骨肉瘤组织中高表达，且与不良预后有关，可能参与到骨肉瘤的发生发展中。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression of Sine oculis homeobox homolog 2 (Six2) in osteosarcoma and its relationship with clinical characteristics and prognosis. Methods: A total of 54 patients with primary osteosarcoma collected were collected as the subjects of this study. Reverse Transcription-Polymerase Chain Reaction(RT-PCR), and immunohistochemistry were used to explore Six2 expression in osteosarcoma. Clinical information was collected and the relationship between Six2 and clinical characteristics of patients with osteosarcoma was analyzed. Patients were followed up for 3 years, recording patient survival data information, and drawing survival analysis curves to explore the relationship between Six2 expression and osteosarcoma prognosis. Results: Six2 was highly expressed in both gene and protein levels in osteosarcoma tissues compared to adjacent normal tissues. The expression of Six2 was correlated with distant metastasis (P<0.05). The higher the expression level of Six2, the worse the prognosis in osteosarcoma patients(P<0.05). Conclusion: Six2 is highly expressed in osteosarcoma tissues and is associated with poor prognosis, which may be involved in the occurrence and development of osteosarcoma. |
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