| 任婷婷,杨艳娥,王彦华,马歆花,齐 雪.热性惊厥患儿血清铁蛋白、同型半胱氨酸和泛酸羟基末端
水解酶L1水平变化及其发病相关性分析[J].,2024,(23):4542-4544 |
| 热性惊厥患儿血清铁蛋白、同型半胱氨酸和泛酸羟基末端
水解酶L1水平变化及其发病相关性分析 |
| Levels of Serum Ferritin, Homocysteine and Hydroxy-terminalHydrolase Pantothenic Acid L1 Levels in Children with Febrile Seizuresand Their Correlation Analysis |
| 投稿时间：2024-08-14 修订日期：2024-09-10 |
| DOI：10.13241/j.cnki.pmb.2024.23.039 |
| 中文关键词: 热性惊厥 铁蛋白 同型半胱氨酸 泛酸羟基末端水解酶L1 |
| 英文关键词: Febrile convulsion Ferritin Homocysteine Ubiquitin C-terminalhydrolase-L1 |
| 基金项目:国科金青年培育项目（24KY0104） |
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| 中文摘要: |
| 摘要 目的：研究热性惊厥患儿血清铁蛋白、Hcy和UCHL-1水平变化，并分析血清铁蛋白、Hcy、UCHL-1与热性惊厥发病的关系。方法：选择2021.1-2024.5我院收治住院的发热患儿160例，其中80例发热患儿发生热性惊厥为研究组，余下80例患儿仅单纯发热为对照组。比较相关指标并进行相关性、诊断价值分析。结果：研究组血清铁蛋白低于对照组，血清Hcy、UCHL-1、IL-6、IL-1β、TNF-α和CRP均高于对照组（P<0.05）。热性惊厥患儿血清铁蛋白、Hcy、UCHL-1与血清炎症因子呈正相关（P<0.05）。ROC曲线显示：血清铁蛋白、Hcy和UCHL-1诊断热性惊厥AUC分别为0.861、0.757和0.906，诊断热性惊厥的特异度和敏感度分别为81.65%和79.23%、73.02%和76.68%、89.35%和88.79%。结论：热性惊厥患儿血清铁蛋白水平下降，而血清Hcy和UCHL-1水平上升，三者均与热性惊厥患儿外周血炎症水平有关，可作为诊断热性惊厥的生物标志物。 |
| 英文摘要: |
| ABSTRACT Objective: Study the changes in serum ferritin, Hcy, and UCHL-1 levels in children with febrile convulsions, and analyze the relationship between serum ferritin, Hcy, and UCHL-1 and the onset of febrile convulsions. Methods: A total of 160 hospitalized febrile children were admitted to 2021.1-2024.5, among which 80 febrile children developed febrile convulsions as the study group, and the remaining 80 children only had simple fever as the control group. Compare the relevant indicators and analyze the correlation and diagnostic value. Results: Serum ferritin was lower in the study group than in the control group, and serum Hcy, UCHL-1, IL-6, IL-1 β, TNF-α, and CRP were all higher than those in the control group (P<0.05). Serum ferritin, Hcy, and UCHL-1 were positively correlated with serum inflammatory factors in children with febrile convulsions (P<0.05). The ROC curve showed that serum ferritin, Hcy and UCHL-1 were 0.861, 0.757 and 0.906, respectively, and the specificity and sensitivity of thermal convulsions were 81.65% and 79.23%, 73.02% and 76.68%, 89.35% and 88.79%, respectively. Conclusion: The level of serum ferritin in children with febrile seizures decreased, while the level of serum Hcy and UCHL-1 increased, and they are related to the level of peripheral blood inflammation in children with febrile seizures and can be used as biomarkers for diagnosing febrile seizures. |
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