| 张赞伟,赵 伟,金 龙,马宏恩,许淑娣.血清IMA、Gal-3与急性ST段抬高型心肌梗死合并HFpEF患者PCI术后心源性猝死的关系研究[J].,2024,(23):4474-4476 |
| 血清IMA、Gal-3与急性ST段抬高型心肌梗死合并HFpEF患者PCI术后心源性猝死的关系研究 |
| Study on the Relationship between Serum IMA, Gal-3 and Sudden Cardiac Death after PCI in Patients with Acute ST-Segment Elevation Myocardial Infarction Complicated with HFpEF |
| 投稿时间：2024-06-18 修订日期：2024-07-15 |
| DOI：10.13241/j.cnki.pmb.2024.23.018 |
| 中文关键词: 急性ST段抬高型心肌梗死 射血分数保留型心力衰竭 缺血修饰白蛋白 半乳糖凝集素-3 经皮冠状动脉介入 心源性猝死 |
| 英文关键词: Acute ST-segment elevation myocardial infarction Heart failure with preserved ejection fraction Ischemia modified albumin Galectin-3 Percutaneous coronary intervention Sudden cardiac death |
| 基金项目:国家自然科学基金项目（81673787） |
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| 中文摘要: |
| 摘要 目的：探讨血清缺血修饰白蛋白（IMA）、半乳糖凝集素-3（Gal-3）与急性ST段抬高型心肌梗死（STEMI）合并射血分数保留型心力衰竭（HFpEF）患者经皮冠状动脉介入（PCI）术后心源性猝死的关系。方法：205例行PCI术的急性STEMI合并HFpEF患者术后随访1年，随访期内45例发生心源性猝死纳入研究组，160例未发生心源性猝死纳入对照组。比较两组患者PCI术前血清 IMA、Gal-3水平。多因素Logistic回归分析患者PCI术后心源性猝死的影响因素。结果：相比于对照组，研究组PCI术前血清IMA、Gal-3水平更高（均P＜0.05）。多因素Logistic回归分析显示，术前血清IMA水平升高、Gal-3水平升高、多支血管病变、心功能Killip 分级为IV级是急性STEMI合并HFpEF患者PCI术后发生心源性猝死的独立危险因素（P＜0.05）。结论：血清IMA、Gal-3水平升高是急性STEMI合并HFpEF患者PCI术后发生心源性猝死的危险因素。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum ischemia modified albumin (IMA), galectin-3 (Gal-3) and sudden cardiac death after percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI) complicated with heart failure with preserved ejection fraction (HFpEF). Methods: 205 patients with acute STEMI complicated with HFpEF who underwent PCI were followed up for 1 year, 45 patients with sudden cardiac death were included in the study group, and 160 patients without sudden cardiac death were included in the control group during the follow-up period. The levels of serum IMA and Gal-3 before PCI were compared between two groups. The influencing factors of sudden cardiac death after PCI were analyzed by multivariate Logistic regression analysis. Results: Compared with control group, the levels of serum IMA and Gal-3 in study group before PCI were higher (all P<0.05). Multivariate Logistic regression analysis showed that, elevated preoperative serum IMA level, elevated Gal-3 level, multi-vessel disease, and cardiac function Killip grade IV were independent risk factors for sudden cardiac death in patients with acute STEMI complicated with HFpEF after PCI (P<0.05). Conclusion: Elevated serum IMA and Gal-3 levels are risk factors for sudden cardiac death in patients with acute STEMI complicated with HFpEF after PCI. |
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