| 胡裕磊,尚晨昊,吉怕伍哈子,李 伟,陈治宏,魏寿江.血清CCR3、CCL7与结直肠癌根治术治疗患者术后复发转移的关系[J].,2024,(23):4470-4473 |
| 血清CCR3、CCL7与结直肠癌根治术治疗患者术后复发转移的关系 |
| Relationship between Serum CCR3, CCL7 and Postoperative Recurrence and Metastasis in Patients Undergoing Radical Resection of Colorectal Cancer |
| 投稿时间：2024-06-18 修订日期：2024-07-10 |
| DOI：10.13241/j.cnki.pmb.2024.23.017 |
| 中文关键词: 结直肠癌 CC趋化因子受体3 CC趋化因子配体7 复发转移 |
| 英文关键词: Colorectal cancer CC chemokine receptor 3 CC chemokine ligand 7 Recurrence and metastasis |
| 基金项目:四川省科技计划项目重点研发计划项目（2022YFS0168） |
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| 中文摘要: |
| 摘要 目的：分析血清CC趋化因子受体3（CCR3）、CC趋化因子配体7（CCL7）与结直肠癌根治术治疗患者术后复发转移的关系。方法：选择我院310例行结直肠癌根治术的患者为研究组和180例健康志愿者为对照组。检测两组血清CCR3、CCL7水平，分析血清CCR3、CCL7与临床病理特征的关系。随访3年，根据预后情况分为未复发转移组及复发转移组。分析术后复发转移的影响因素。结果：与对照组相比，研究组血清CCR3、CCL7水平更高（P<0.05）。有淋巴结转移、TNM分期III期患者血清CCR3、CCL7水平显著高于无淋巴结转移、TNM分期I~II期患者（P<0.05）。复发转移组血清CCR3、CCL7水平显著高于未复发转移组（P<0.05）。结肠癌患者术后复发转移的危险因素包括淋巴结转移、CCR3升高、CCL7升高（P<0.05）。结论：结直肠癌患者血清CCR3、CCL7水平升高，且是术后复发转移的危险因素。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the relationship between serum CC chemokine receptor 3 (CCR3), CC chemokine ligand 7 (CCL7) and postoperative recurrence and metastasis in patients undergoing radical resection of colorectal cancer. Methods: 310 patients who underwent radical resection of colorectal cancer were selected as the study group, and 180 healthy volunteers as the control group. serum levels of CCR3 and CCL7 in two groups were detected. The relationship between serum CCR3 and CCL7 and clinical pathological features was ananlyzed. Followed up for 3 years and divided into non-recurrence and metastasis group and recurrence and metastasis group based on prognosis. The influencing factors of postoperative recurrence and metastasis were analyzed. Results: Compared with the control group, the study group had higher levels of serum CCR3 and CCL7 (P<0.05). The serum levels of CCR3 and CCL7 in patients with lymph node metastasis and TNM stage III were significantly higher than those in patients without lymph node metastasis and TNM stage I~II (P<0.05). The serum levels of CCR3 and CCL7 in recurrence and metastasis group were significantly higher than those in non-recurrence and metastasis group (P<0.05). The risk factors for postoperative recurrence and metastasis in colorectal cancer patients included lymph node metastasis, elevated CCR3, and elevated CCL7 (P<0.05). Conclusion: Elevated serum levels of CCR3 and CCL7 in colorectal cancer patients are risk factors for postoperative recurrence and metastasis. |
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