| 崔风然,张 斐,任志龙,陈 杰,陈邦第.积雪苷片联合点阵CO2激光对瘢痕疙瘩患者心理状态、
炎症因子和血清VEGF、EGF的影响
[J].,2024,(23):4467-4469 |
| 积雪苷片联合点阵CO2激光对瘢痕疙瘩患者心理状态、
炎症因子和血清VEGF、EGF的影响
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| Effects of Jixuoside Tablets Combined with Lattice CO2 Laser on the Psychological State, Inflammatory Factors, and Serum VEGF and EGF of Patients with Scar Tissue |
| 投稿时间：2024-06-18 修订日期：2024-07-15 |
| DOI：10.13241/j.cnki.pmb.2024.23.016 |
| 中文关键词: 积雪苷片 点阵CO2激光 瘢痕疙瘩 心理状态 炎症因子 血管内皮生长因子 表皮细胞生长因子 |
| 英文关键词: Jixuoside tablets Lattice CO2 laser Keloids Psychological state Inflammatory factors Vascular endothelial growth factor Epidermal cell growth factor |
| 基金项目:湖南省自然科学基金青年基金项目（2021JJ40487） |
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| 中文摘要: |
| 摘要 目的：探讨积雪苷片联合点阵CO2激光对瘢痕疙瘩患者心理状态、炎症因子和血清血管内皮生长因子（VEGF）、表皮细胞生长因子（EGF）的影响。方法：采用计算机产生随机数将118例瘢痕疙瘩患者随机分为观察组（n=59）和对照组（n=59）。对照组患者接受积雪苷片治疗，观察组患者接受积雪苷片联合点阵CO2激光治疗。对比两组治疗前后的相关量表评分、瘢痕情况（宽度、长度、硬度）、心理状态、血清炎症因子、VEGF、EGF。结果：两组治疗后温哥华瘢痕量表（VSS）、视觉模拟评分法（VAS）、焦虑自评量表（SAS）、抑郁自评量表（SDS）评分、瘢痕宽度、长度、硬度下降，且观察组低于对照组（P<0.05）。两组治疗后血清白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、VEGF、EGF下降，且观察组低于对照组；血清γ-干扰素（TFN-γ）升高，且观察组高于对照组（P<0.05）。结论：积雪苷片联合点阵CO2激光治疗瘢痕疙瘩患者，可有效抑制炎症因子和调节血清VEGF、EGF水平，减轻焦虑抑郁状态，治疗效果良好。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effects of Jixuoside tablets combined with lattice CO2 laser on the psychological state, inflammatory factors, serum vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF) of patients with scar tissue. Methods: A total of 118 patients with scar tissue were randomly divided into observation group (n=59) and control group (n=59) by random number generated by computer. The control group received treatment with jixuoside tablets, while the observation group received a combination of jixuoside tablets and dot matrix CO2 laser. Compare the clinical efficacy, relevant scale scores, scar condition (width, length, hardness), psychological status, inflammatory factors, VEGF, EGF. Results: After treatment, the Vancouver Scar Scale (VSS), Visual Analog Scale (VAS), Self Rating Anxiety Scale (SAS), Self Rating Depression Scale (SDS) scores, scar width, length and hardness decreased in both groups, and the observation group was lower than the control group (P<0.05). After treatment, serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), VEGF and EGF decreased in the two groups, and those in the observation group were lower than the control group. Serum γ-interferon (TFN-γ) increased, and the observation group was higher than the control group (P<0.05). Conclusion: The combination of jixuoside tablets and dot matrix CO2 laser therapy may improve alleviate anxiety and depression in patients with scar tissue by inhibiting the activity of inflammatory factors and regulating serum VEGF and EGF levels. The effect is good. |
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