| 黄 莹,孙煦勇,廖吉祥,曹 嵩,苏庆东.血清巨噬细胞炎性蛋白-1α、中性粒细胞与淋巴细胞计数比值
与肾移植受者术后肺部感染风险的关系分析[J].,2024,(23):4461-4463 |
| 血清巨噬细胞炎性蛋白-1α、中性粒细胞与淋巴细胞计数比值
与肾移植受者术后肺部感染风险的关系分析 |
| Analysis of the Relationship between Serum Macrophage Inflammatory Protein-1α, Neutrophil to Lymphocyte Count Ratio and the Risk of Pulmonary Infection after Renal Transplantation |
| 投稿时间：2024-06-05 修订日期：2024-06-29 |
| DOI：10.13241/j.cnki.pmb.2024.23.014 |
| 中文关键词: 肾移植 肺部感染 巨噬细胞炎性蛋白-1?琢 中性粒细胞与淋巴细胞计数比值 |
| 英文关键词: Renal transplantation Pulmonary infection Macrophage inflammatory protein-1?琢 Neutrophil to lymphocyte count ratio |
| 基金项目:广西壮族自治区卫生健康委员会自筹经费科研课题项目（Z20200653） |
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| 中文摘要: |
| 摘要 目的：分析血清巨噬细胞炎性蛋白-1α（MIP-1α）、外周血中性粒细胞与淋巴细胞计数比值（NLR）与肾移植受者术后肺部感染风险的关系。方法：选择308例接受肾移植的患者，根据患者术后是否发生肺部感染分为未感染组（n=253）、感染组（n=55），对比两组血清MIP-1α、外周血NLR。多因素logistic回归分析影响术后肺部感染发生的危险因素。结果：308例肾移植受者术后1年肺部感染发生率为17.86%。感染组血清MIP-1α、外周血NLR比未感染组高（P＜0.05）。肾移植受者术后肺部感染的独立危险因素为MIP-1α升高、NLR升高、PCT升高、有吸烟史（P＜0.05）。结论：肾移植受者血清MIP-1α及外周血NLR上升会增加术后肺部感染发生风险。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the relationship between serum macrophage inflammatory protein-1α (MIP-1α), peripheral blood neutrophil to lymphocyte count ratio (NLR) and the risk of pulmonary infection after renal transplantation. Methods: 308 patients who underwent renal transplantation were selected, which were divided into uninfected group (n=253) and infected group (n=55) according to whether pulmonary infection occurred after operation. Serum MIP-1α and peripheral blood NLR were compared in two groups. The risk factors affecting the occurrence of postoperative pulmonary infection were analyzed by multivariate logistic regression analysis. ABSTRACT: The incidence of pulmonary infection in 308 renal transplant recipients was 17.86% at 1 year after operation. The serum MIP-1α and peripheral blood NLR in infected group were higher than those in uninfected group (P<0.05). The independent risk factors for postoperative pulmonary infection in renal transplant recipients were increased MIP-1α, increased NLR, increased PCT, and smoking history (P<0.05). Conclusion: The increase of serum MIP-1α and peripheral blood NLR in renal transplant recipients will increase the risk of postoperative pulmonary infection. |
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