| 王 敏,孙志敏,周 跃,顾文婷,孙杏红.血清asprosin、microRNA-20a-5p、miR-137在糖尿病性视网膜病变的水平变化及临床意义[J].,2024,(22):4393-4396 |
| 血清asprosin、microRNA-20a-5p、miR-137在糖尿病性视网膜病变的水平变化及临床意义 |
| Level Changes and Clinical Significance of Serum Asprosin, microRNA-20a-5p, and miR-137 in Diabetic Retinopathy |
| 投稿时间：2024-06-12 修订日期：2024-07-06 |
| DOI：10.13241/j.cnki.pmb.2024.22.058 |
| 中文关键词: 2型糖尿病 糖尿病性视网膜病变 asprosin 微RNA-20a-5p 微RNA-137 |
| 英文关键词: Type 2 diabetes Diabetic retinopathy Asprosin miR-20a-5p miR-137 |
| 基金项目:江苏省自然科学基金项目（BK2020096） |
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| 中文摘要: |
| 摘要 目的：探讨血清asprosin、microRNA-20a-5p、miR-137在糖尿病性视网膜病变的水平变化及临床意义方法：选取2022.4-2024.4于医院收治的2型糖尿病患者（T2DM组）120例，并根据是否发生DR分为DR组60例，非DR组60例，在DR组内按照疾病的严重程度分为PDR40例以及NPDR20例，选取40例健康体检者为对照组，对比分析相关指标。结果：与对照组相比asprosin、miR-137在T2DM患者中均升高，miRNA-20a-5p降低（P＜0.05）。DR组患者年龄、HbA1、FPG、LDL-C、asprosin、miR-137高于NDR组，病程长于NDR组，miR-20a-5p低于NDR组（P＜0.05）。PDR组中病程、空腹血糖、糖化血红蛋白、asprosin和miR-137高于NPDR组，miR-20a-5p低于NPDR组（P＜0.05）。病程、空腹血糖、糖化血红蛋白、asprosin和miR-137属于DR发生的独立危险因素，而miR-20a-5p为独立保护因素。结论：血清中asprosin、microRNA-20a-5p、miR-137的水平变化T2DM并发DR密切相关，可能成为DR防治的监测指标及靶点。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the changes and clinical significance of serum asprosin, microRNA-20a-5p, and miR-137 levels in diabetic retinopathy. Methods: 120 patients (T2DM group) with type 2 DM were selected for 2022.4-20240 patients in DR group, 60 patients in non-DR group, and 40 PDR and NPDR20 cases in DR group, 40 healthy examination patients were selected as the control group, and relevant indicators were analyzed. Results: Compared with controls, asprosin and miR-137 were increased in T2DM patients, and miRNA-20a-5p was decreased (P<0.05). In the DR group, their age, HbA 1, FPG, LDL-C, asprosin, and miR-137 were higher than the NDR group, their disease duration was longer than the NDR group, and their miR-20a-5p was lower than the NDR group (P<0.05). In the PDR group, disease course, fasting glucose, hemoglobin A 1 c, asprosin and miR-137 were higher than that in the NPDR group, miR-20a-5p was lower than that in the NPDR group (P<0.05). Disease duration, fasting glucose, HbA 1 c, asprosin and miR-137 were independent risk factors for the development of DR, while miR-20a-5p was an independent protective factor. Conclusion: The levels of asprosin, microRNA-20a-5p and miR-137 in serum are closely related between T2DM and DR, which may become the monitoring index and target of DR prevention and treatment. |
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