| 王 莹,米 佳,杨延星,王晓慧,宜晓茸.超声大脑中动脉血流参数对脑小血管疾病患者脑白质病变程度的评估价值研究[J].,2024,(22):4382-4384 |
| 超声大脑中动脉血流参数对脑小血管疾病患者脑白质病变程度的评估价值研究 |
| Value of Ultrasound Blood Flow Parameters of Middle Cerebral Artery in Evaluating the Degree of White Matter Lesions in Patients with Cerebral Small Vessel Disease |
| 投稿时间：2024-04-28 修订日期：2024-05-20 |
| DOI：10.13241/j.cnki.pmb.2024.22.055 |
| 中文关键词: 脑小血管疾病 脑白质病变 大脑中动脉平均血流速度 搏动指数 屏气指数 评估价值 |
| 英文关键词: Cerebral small vessel disease White matter lesions Mean blood flow velocity of middle cerebral artery Pulsatility index Breath holding index Evaluation value |
| 基金项目:陕西省教育厅专项科研计划项目（20JG040） |
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| 中文摘要: |
| 摘要 目的：分析超声大脑中动脉血流参数对脑小血管疾病（CSVD）患者脑白质病变（WLMs）程度的评估价值。方法：选取2021年1月至2024年1月期间延安大学附属医院收治的98例CSVD患者为研究组，另选取同期60例体检健康者为对照组，按照WLMs严重程度分为轻度组（n=42）、中度组（n=36）及重度组（n=20），通过超声检查收集受试者超声大脑中动脉收缩期峰值血流速度（Vs）、舒张期峰值血流速度（Vd）、平均血流速度（Vm）、搏动指数（PI）及屏气指数（BHI），对比研究组与对照组、不同WLMs严重程度的大脑中动脉血流参数。结果：研究组Vs、Vd、Vm及BHI均低于对照组，PI较对照组更高（P<0.05）。3组患者大脑中动脉血流参数对比存在显著差异（P<0.05）；与轻度组对比，中、重度组Vs、Vd、Vm及BHI均下降，PI升高（P<0.05）；重度组Vs、Vd、Vm及BHI均低于中度组，PI高于中度组（P<0.05）。结论：超声大脑中动脉血流参数与CSVD患者WLMs严重程度呈显著相关，可作为早期评估WLMs严重程度的无创指标。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the value of ultrasound blood flow parameters of middle cerebral artery in evaluating the degree of white matter lesions (WMLs) in patients with cerebral small vessel disease (CSVD). Methods: A total of 98 patients with CSVD who were admitted to Yan'an University Affiliated Hospital between January 2021 and January 2024 were selected as the study group. Meanwhile, 60 healthy individuals were selected as the control group. The patients were divided into mild group (n=42), moderate group (n=36) and severe group (n=20) according to the severity of WMLs. Ultrasound examination was conducted to collect peak systolic blood flow velocity (Vs), peak diastolic blood flow velocity (Vd), mean blood flow velocity (Vm), pulsatility index (PI) and breath holding index (BHI) of middle cerebral artery. The blood flow parameters of middle cerebral artery were compared between the study group and the control group as well as among patients with different severity of WMLs. Results: Vs, Vd, Vm and BHI of the study group were lower than those of the control group, and PI was higher than that of the control group (P<0.05). There were significant differences in blood flow parameters of middle cerebral artery among patients with different severity of WMLs (P<0.05). Compared with mild group, there were decreases in Vs, Vd, Vm and BHI, and increases in PI in moderate group and severe group (P<0.05). Compared with moderate group, there were decreases in Vs, Vd, Vm and BHI, and increase in PI in severe group (P<0.05). Conclusion: Ultrasound blood flow parameters of middle cerebral artery are significantly correlated with the severity of WMLs in patients with CSVD, and can serve as non-invasive indicators for early evaluation of the severity of WMLs. |
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